Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an inorganic compound
Patent
1996-11-01
1997-08-05
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an inorganic compound
A61K 5100
Patent
active
056539576
ABSTRACT:
A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
REFERENCES:
patent: 5256394 (1993-10-01), Spielvogel
patent: 5455022 (1995-10-01), Miura et al.
patent: 5489673 (1996-02-01), Wilbur
Knoth et al., "Chemistry of Boranes" Inorg. Chem., 3(2), pp. 159-167 1964.
Knoth et al., "Chemistry of Boranes", J. Am. Chem. Soc., 86, pp. 3972-3983 1964.
Miura Michiko
Slatkin Daniel N.
Associated Universities Inc.
Bogosian M. C.
Kelley Lara C.
Kight John
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