Halogenated pyrimidine nucleosides and their derivatives

Details Halogenated pyrimidine nucleosides and their derivatives Halogenated pyrimidine nucleosides and their derivatives

1988-12-29

1990-07-17

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514917, 562553, C07H 19073, A61K 31505, A61K 31195, A61K 31215

Patent

active

049422260

ABSTRACT:
Halogenated pyrimidine nucleoside derivatives with improved aqueous solubility and methods of enhancing the concentration of drugs in malignant tumors and promoting uniform distribution of the drug throughout the tumor. These basic and hydrophilic ester prodrugs are designed to undergo conversion to the active drug by an intramolecular chemical reaction at practical rates under physiological conditions.

REFERENCES:
patent: 4603133 (1986-07-01), Engelhardt et al.
patent: 4731369 (1988-03-01), Engelhardt et al.
Coleman, Journal of the National Cancer Institute vol. 80, No. 5 pp. 310-317 (1988).

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