Halogenated prostacyclins pharmaceutical use thereof and hydroxy

Details Halogenated prostacyclins pharmaceutical use thereof and hydroxy Halogenated prostacyclins pharmaceutical use thereof and hydroxy

1981-12-04

1984-09-18

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

549214, 549305, 549414, 549465, A61K 31557, C07D307935

Patent

active

044724284

ABSTRACT:
Novel 5- or 7-monohalogenated or 5,7-dihalogenated .sup.6 -PGI.sub.1 and 5- or 7-monohalogenated or dihalogenated PGI.sub.2 (except 5-monofluorinated PGI.sub.2). The novel halogenated prostacyclins are useful for controlling vascular actions and also in organ transplantation, extra-corporeal circulation and the like. The present invention also provides processes for preparing the novel halogenated prostacyclins.

REFERENCES:
Stringfellow et al., Nature, vol. 282, (1979), pp. 76-78.
Science, vol. 212, (1981), pp. 1270-1272.
Japanese Publication No. 136161/1977 (& Derwent Abstract).
Japanese Publication 95644/1977 (& Derwent Abstract).
Japanese Publication 501,319/1981 (Corresponding to WO81/01002) [& Derwent Abstract].

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