Halogenated ester derivatives of coumarins for the treatment...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S457000

Reexamination Certificate

active

07932405

ABSTRACT:
The subject invention provides anticoagulant compounds of formula I:and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subject invention can be used to treat at-risk populations thereby bringing relief of symptoms, improving the quality of life, preventing acute and long-term complications, reducing mortality and treating accompanying disorders. The invention further comprises pharmaceutical compositions comprising the compounds and salts of the invention, as well as methods of using the compounds, salts, and compositions of the invention.

REFERENCES:
patent: 5510375 (1996-04-01), Domagala et al.
patent: 5686486 (1997-11-01), Tomich et al.
patent: 6864279 (2005-03-01), Druzgala et al.
patent: 7253208 (2007-08-01), Druzgala et al.
patent: 7285671 (2007-10-01), Druzgala et al.
patent: 2004/0058985 (2004-03-01), Carter
patent: 2004/0220258 (2004-11-01), Druzgala et al.
patent: 02/085882 (2002-10-01), None
patent: 2004/058985 (2004-03-01), None
Wakefield, Basil “Fluorinated Pharmaceuticals” Innovations in Pharmaceutical Technology 2003, 74, 76-78, Online “http://web.archive.org/web/20030905122408/http://www.iptonline.com/articles/public/IPTFOUR74NP.pdf.” (accessed via Wayback machine Nov. 20, 2009 showing web availability as of Sep. 2003).
Patani et. al. “Bioisosterism: A Rational Approach in Drug Design” Chemical Reviews 1996, 96, 3147-3176.
Wikianswers “http://wiki.answers.com/Q/What—is—a—substituted—hydrocarbon” online accessed Sep. 1, 2010.
Jones et al., “Solvolysis Mechanisms. Sn1-Like Behavior of Methyl Chloromethyl Ether. Sensitivity to Solvent Ionizing Power and α-Deuterium Isotope Effect, ” Journal of the American Chemical Society, 89, 4863-4867 (1967).
DeRuiter, “Resonance and Induction Tutorial,” Principles of Drug Action 1, Spring 2005, Resonanec and Induction, Online “http://www.auburn.edu/˜deruija/pda1—resonance.pdf” accessed Jun. 22, 2009.
Tou et al., “Kinetic Study of the Stabilities of Chloromethyl Methyl Ether and Bis(Chloromethyl) Ether in Humid Air,” Analytical Chemistry, 46, 1866-1869 (1974).
Theopold et al., “Coagulation in arthropods: defence, wound closure and healing,” Trends in Immunology, 25(6), 289 (2004).
McMaster Hematology Program online “http://fhs.mcmaster.ca/hemares/designduration.htm” accessed Oct. 17, 2008.
Oldenburg, J. et al., Chapter 3 “The Vitamin K Cycle,” Vitamins and Hormones, 78:35-62 (2008).
Mann et al., “Biochemistry and Physiology of Blood Coagulation,” Thrombosis and Haemostasis, 82(2):165-174 (1999).
“Coumadin Tablets,” Online “http://www.fda.gov/cder/foi/label/2007/009218s105lblv2.pdf,” accessed Oct. 20, 2008.
Nurden et al., “Inherited disorders of platelets: an update,” Current Opinion in Hematology, 13:157-162 (2006).
Dahl et al., “The Reactivity of Affinity Labels: A Kinetic Study of the Reaction of Alkyl Halides with Thiolate Anions—a Model Reaction for Protein Aklylation,” Bioorganic Chemistry, 10:329-341 (1981).
Castro et al., “Biodehalogenation. Reductive Reactivities of Microbial and Mammalian Cytochromes P-450 Compared with Heme and Whole-Cell Models,” Journal of Agricultural & Food Chemistry, 36, 915-919 (1988).
Wheeler et al., “Conjugation of Haloalkanes by Bacterial and Mammalian Glutathione Transferases: Mono- and Vicinal Dihaloethanes,” Chemical Research in Toxicology, 14, 1107-1117 (2001).
Goodstadt et al., “Vitamin K epoxide reductase: homology, active site and catalytic mechanism,” Trends in Biochemical Sciences, 29(6):289-292 (2004).
Johnson, A.W., Invitation to Organic Chemistry, Jones and Bartlett: Mississauga, Canada, p. 24 (1999).
Horton et al., “Reactions with Reactive Alkyl Halides,” Methods in Enzymology, 11, 556-565 (1967).

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