Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1990-09-28
1992-03-17
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 54, 548344, 548496, 548535, 560 39, 560 41, 560153, 560169, 560172, 562448, 562449, 562556, 562561, 562564, 562567, 562574, 564154, 564155, 564157, 564158, 564159, 514400, 514419, 514423, 514542, 514550, 514561, 514562, 514563, 514616, A61K 718, C07C22900, C07C23300
Patent
active
050967002
ABSTRACT:
The subject invention involves halogenated amino acid derivatives useful as antimicrobial agents having the structure: ##STR1## wherein --R is hydrogen or 2-aminoethyl; --R' is hydroxy, alkoxy, aryloxy, or an amino acid residue bonded at the amino nitrogen; --R" is hydrogen or an amino acid residue bonded at the carbonyl carbon; --X is halogen; and --Y is hydrogen or halogen.
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Goodacre, J., L. Jeffries, J. H. C. Nayler, R. J. Ponsford & I. Sterling, "Antibacterial Halogenoacetyl Derivatives of Amino Acids and Simple Peptides", Journal of Medicinal Chemistry, vol. 20, No. 11 (1977), pp. 1445-1448.
Johnston, M., P. Marcotte, J. Donovan & C. Walsh, "Mechanistic Studies with Vinylglycine and .beta.-Haloaminobutyrates as Substrates for Cystathionine .gamma.-Synthetase from Salmonella typhimurium", Biochemistry, vol. 18, No. 9 (1979), pp. 1729-1738.
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Gardner Joseph H.
Seibel William L.
Graff IV Milton B.
Shippen Michael L.
The Procter & Gamble & Company
Witte Richard C.
Yetter Jerry J.
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