Halogen substituted mitomycin derivatives

Details Halogen substituted mitomycin derivatives Halogen substituted mitomycin derivatives

1991-09-05

1993-06-08

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704

Patent

active

052181260

ABSTRACT:
Disclosed are mitomycin derivatives of formula (I): ##STR1## where W represents halogen; X represents methoxy, amino or ethylenimino; Y represents hydrogen or methyl; Z represents hydrogen or methyl; and one of R.sup.1 and R.sup.2 represents carbamoyloxymethyl, and the other represents hydrogen. The derivatives are usable as an antitumor and antibacterial agent.

REFERENCES:
patent: 4880825 (1989-11-01), Kasai et al.
Iyengar et al., J. Med. Chem (1983) No. 26, pp. 1453-1457.
Kinoshita et al., J. Med. Chem (1971), vol. 14, No. 2, pp. 103-109.

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