Halogen substituted benzopyran- and benzothiopyran-4-carboxylic

Details Halogen substituted benzopyran- and benzothiopyran-4-carboxylic Halogen substituted benzopyran- and benzothiopyran-4-carboxylic

1978-11-08

1980-07-01

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

549 23, 2603452, 2603455, 424283, A61K 3138, A61K 3135, C07D31104, C07D33506

Patent

active

042106630

ABSTRACT:
Novel halogen-substituted benzopyran-4-carboxylic acids, benzothiopyran-4-carboxylic acids and derivatives thereof useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Specific compounds disclosed include 6-phenyl-8-chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6,7-dichloro-3,4-dihydrobenzothiopyran-4-carboxylic acid, 6-chloro-8-methyl-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6,8-dichloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-chloro-dihydro-2H-naphtho[1,2-b]pyran-4-carboxylic acid, 6-chloro-3,4-dihydro-2H-1-benzothiopyran-4-carboxylic acid and 6-chloro-3,4-dihydro-2H-1-benzopyran-4-acetic acid. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of using the novel compounds for the treatment of chronic diabetic complications.

REFERENCES:
Ann. Chim. Paris, No. 3, 179 (1968) (Maitte).
Chem. Abs. 75 98400b (1971) (Witiak et al.).
Chem. Abs. 82 57517w (1975) (Zaugg et al.).

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