Halogen substituted .alpha.-(aminoalkyl)-3,4-dihydroxybenzyl alc

Details Halogen substituted .alpha.-(aminoalkyl)-3,4-dihydroxybenzyl alc Halogen substituted .alpha.-(aminoalkyl)-3,4-dihydroxybenzyl alc

1970-01-13

1976-08-24

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602485, 2603437, 260348R, 26050111, 26050112, 26050117, 26050118, 26050119, 2605705C, 260592, 260599, 260600R, 424280, 424316, 424330, C07C 9122

Patent

active

039766950

ABSTRACT:
Halogen substituted .alpha.-(aminoalkyl)-3,4-dihydroxybenzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators. The .alpha.-aminomethyl derivatives are prepared by the condensation of an appropriately substituted styrene oxide with a primary amine followed by removal of the ether protective group(s). The .alpha.-aminoethyl or .alpha.-aminopropyl derivatives are prepared by the condensation of an appropriately substituted .alpha.-bromoalkyl phenyl ketone with an N-benzyl secondary amine followed by reduction of the ketone moiety and removal of the ether protective group(s).

REFERENCES:
lundholm et al., "Acta. Pharmacol. Toxicol.", vol. 20, No. 4, pp. 303-308 (1963).
Chemical Abstracts, "Subject Index A-I", vol. 61, p. 400s (1964).
Chemical Abstracts, "Formula Index", vol. 61, p. 271f (1964).

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