Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-10-15
1999-10-19
Jones, Dwayne C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514895, 564370, A61K 31205
Patent
active
059689870
ABSTRACT:
The present invention relates to the use of halofantrine free base in the treatment of malarial infections. In particular, lipid-based formulations for oral and injectable use are disclosed.
REFERENCES:
patent: 4507288 (1985-03-01), Rosignol
patent: 4818767 (1989-04-01), Rossignol
patent: 5278173 (1994-01-01), Davis
Nothdurft et al., "Halofantrine: a new substance for treatment of multidrug-resistant malaria", Clincal Investig, 71:69-73, (1993).
Shah et al., "Self-emulsifying drug delivery systems (SEDDS) for improving in vitro dissolution and oral absorption of lipophilic drugs", Bull. Tech/Gattefosse Rep., vol. 85, pp. 45-54, 1993.
Charman William Neil
Porter Christopher John Hamilton
Jones Dwayne C.
King William T.
Kinzig Charles M.
Simon Soma G.
SmithKline Beecham p.l.c.
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