Haloethyl-substituted steroid enzyme inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514178, 514182, 552526, 552615, 552632, 552650, 552651, A61K 3156, C07J 100

Patent

active

052525651

ABSTRACT:
The present invention is directed to a group of compounds which are haloethyl substituted steroidal enzyme inhibitors. These compounds are useful as aromatase, 19-hydroxylase, and aldosterone biosynthesis inhibitors and they are prepared from the corresponding epoxide.

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Marcotte, et al. "Synthesis and Evaluation of 10.beta.-Substituted 4-Estrene-3,17-Diones as Inhibitors of Human Placental Microsomal Aromatase." Steroids, 39(3), Mar. 1982, pp. 325-344.
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Childers et al., J. Org. Chem., 53, 5947 (1988).
Morrison and Boyd, "Organic Chemistry" (Boston, Allyn and Bacon 1979) pp. 564, 568, 569.

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