Halocyclopropyl substituted phenoxyalkanoic acids

Details Halocyclopropyl substituted phenoxyalkanoic acids Halocyclopropyl substituted phenoxyalkanoic acids

1974-02-19

1976-04-06

Terapane,

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465F, 260473F, 2605011, 26050117, 260612R, 260578, 260612D, 260619D, 260621R, 424308, 424316, 424317, 260520C, C07C 6976

Patent

active

039489736

ABSTRACT:
Halocyclopropyl substituted phenoxyalkanoic acids and esters thereof, having hypocholesteremic activity are prepared via several alternative synthetic approaches, involving as the key reactions interaction of a substituted phenylalkene with a carbene source to introduce the halocyclopropyl moiety, and reaction of a substituted phenol with chloroform and a lower-alkanone in the presence of base, or with a lower-alkyl .alpha.-bromo-alkanoate, to form the phenoxyalkanoic acid moiety.

REFERENCES:
patent: 3362997 (1968-01-01), Bolhofer
patent: 3363003 (1968-01-01), Bolhofer
patent: 3383411 (1968-05-01), Schultz et al.
patent: 3598860 (1971-08-01), Griot
patent: 3598862 (1971-08-01), Griot
patent: 3694512 (1972-09-01), Narayanan
patent: 3839431 (1974-10-01), Sheehan
Burger, "Medicinal Chemistry," Wiley-Interscience, N.Y., (1970), pp. 71, 72.

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