Haloacetoacetate reductase, method for producing said enzyme, an

Details Haloacetoacetate reductase, method for producing said enzyme, an Haloacetoacetate reductase, method for producing said enzyme, an

1998-12-22

1999-12-14

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435 711, 435135, 435280, C12N 906, C12P 762

Patent

active

060016183

ABSTRACT:
A novel enzyme is provided. This enzyme is capable of reducing 4-haloacetoacetic acid esters to produce (S)-4-halo-3-hydroxybutyric acid esters with high optical purity. The enzyme was isolated from a microorganism belonging to the genus Kluyveromyces. Using the enzyme, (S)-4-halo-3-hydroxybutyric acid esters, which are useful as HMG-CoA reductase inhibitors, intermediates for synthesizing various medicines and agricultural chemicals, can be efficiently produced with high optical purity.

REFERENCES:
patent: 5413921 (1995-05-01), Onishi et al.
patent: 5559030 (1996-09-01), Matsuyama et al.
patent: 5780649 (1998-07-01), Yuasa et al.
patent: 5891685 (1999-04-01), Yamagishi et al.
Heidlas et al., "Purification and Characterization of two Oxidoreductases Involved in the Enantioselective Reduction of 3-oxo, 4-oxo and 5-oxo Esters in Baker's Yeast", Eur. J. Biochem. 172:633-639, 1988.
Kataoka et al., "A Novel NADPH-Dependent Carbonyl Reductase of Candida Macedoniensis: Purification and Characterization", Archives of Biochemistry and Biophysics 294:469-474, 1992.
Nakamura et al., "Stereochemical Control of Microbial Reduction. 17. A Method for Controlling the Enantioselectivity of Reductions with Bakers' Yeast", J. Org. Chem. 56:4778-4783, 1991.
Patel et al., "Stereoselective Reduction of .beta.-Keto Esters by Geotrichum Candidum", Enzyme Microb. Technol. 14:731-738, 1992.
Shieh et al., "Stereochemical Control of Yeast Reductions. 5. Characterization of the OxidoreductasesInvolved in the Reduction of .beta.-Keto Esters", J. Am. Chem. Soc. 107:2993-2994, 1995.

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