Halo-substituted bisindolemaleimide protein kinase C inhibitors

Details Halo-substituted bisindolemaleimide protein kinase C inhibitors Halo-substituted bisindolemaleimide protein kinase C inhibitors

1997-04-30

1999-08-10

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514183, 514185, 514410, 540450, 540456, 540467, 540472, 640480, 640474, C07D26900, C07D41314, A61K 3155, A61K 31395

Patent

active

059360844

ABSTRACT:
The present invention is directed to novel halo-substituted bis-indolemaleimide compounds of the formula: ##STR1## The invention further provides a method of preparing the disclosed compounds and the preparation of pharmaceutical formulation for use in inhibiting Protein Kinase C in mammals.

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patent: 5624108 (1997-04-01), Heath et al.
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"A Short Synthesis of 2-Deoxy-2-fluoro-ribo-D-pentopyranose", Welch et al., J. Chem. Soc., Chem. Commun., pp. 186-188, 1985.

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