Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-11-12
2000-05-30
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544370, A61K 31496, C07D40306
Patent
active
060691468
ABSTRACT:
The present invention provides a substantially purified compound having the structure: ##STR1## wherein R.sub.1 to R.sub.9 are defined; or a salt of the compound, and provides pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier. The invention also provides methods of reducing or inhibiting mitosis of a cell by contacting the cell with a compound of the invention, which blocks the cell at the G2/M phase of the cell cycle. The invention also provides a method of reducing the severity of a pathology characterized, at least in part, by undesirable proliferation of a population of cells in a subject by administering to the subject a compound of the invention in an amount sufficient to reduce or inhibit proliferation of the population of cells.
REFERENCES:
patent: 5891877 (1999-04-01), Brocchini et al.
Fukumoto et al., Chemical Abstracts, vol. 129, No. 53444 (Abstract for JP 10130266, May 19, 1998), 1999.
Kanoh et al., Bioorganic & Medicinal Chemistry Letters vol. 7, No. 22 pp. 2847-2852, 1997.
Cheng Xing C.
Fenical William
Jensen Paul R.
Bernhardt Emily
The Regents of the University of California
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