Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-07-29
1998-07-28
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549344, C07D31300, C07D49322
Patent
active
057864926
ABSTRACT:
Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R.sup.1 and R.sup.2 together form a spiro attached ring system selected from the group consisting of: ##STR2##
REFERENCES:
J. Med. Chem. 34(11), pp. 3339-3340; Pettit, 1991.
Tetrahedron Letters, 28(30), pp. 3463-3466; Alcher et al; 1987.
J. Am. Chem. Soc., 107(16), pp. 4796-4798; Uemura et al; 1985.
Pure & Appl. Chem., Halichondrins--antitumor polyether macrolides from a marine sponge, vol. 58, No. 5, pp. 701-710; 1986.
Blunt John W.
Gravalos Dolores G.
Lake Robin J.
Litaudon Marc S. P.
Munro Murray H. G.
Linek Ernest V.
Pharma Mar S.A.
Trinh Ba K.
LandOfFree
Halichondrins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Halichondrins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Halichondrins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-24700