Hairpin ribozymes

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353201, 435325, 435354, C07H 2104, C12N 506, C12N 1563

Patent

active

058378553

ABSTRACT:
Hairpin ribozyme lacking a substrate moiety, comprising at least six bases in helix 2 and able to base-pair with a separate substrate RNA, wherein the said ribozyme comprises one or more bases 3' of helix 3 able to base-pair with the said substrate RNA to form a helix 5 and wherein the said ribozyme can cleave and/or ligate said separate RNA(s) in trans.

REFERENCES:
patent: 5334711 (1994-08-01), Sproat et al.
Anderson et al., "Mutagenesis of the hairpin ribozyme," Nucleic Acids Research 22:1096-1100 (1994).
Ballantyne et al., "Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1)," Nucleic Acids Research 17:5853 (1989).
Barinaga, "Ribozymes: Killing the Messenger," Science 262:1512-1514 (1993).
Benseler et al., "Hammerhead-like Molecules Containing Non-Nucleoside Linkers Are Active RNA Catalysts," J. Am. Chem. Soc. 115:8483-8484 (1993).
Berzal-Herranz et al., "In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed clevage and ligation reactions," Genes & Development 6:129-134 (1992).
Berzal-Herranz et al., "Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme," EBMO J. 12:2567-2574 (1993).
Carter, "Adeno-Associated Virus Vectors," Curr Opi. Biotech. 3:533-539 (1992).
Cech, "Ribozyme Engineering," Current Opinion in Structural Biology 2:605-609 (1992).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira et al., "Four Ribose 2'-Hydroxyl Groups Essential for Catalytic Function of the Hairpin Ribozyme," J. Biol. Chem. 268:19458-19462 (1993).
Chowrira and Burke, "Binding and Cleavage of Nucleic Acids by the Hairpin Ribozyme," Biochemistry 30:8518-8522 (1991).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Acitve and Nuclease- Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Cotten, "The in vivo application of ribozymes," TIBTECH 8:174-178 (1990).
Edgington, "Ribozymes: Stop Making Sense," Biotechnology 10:256-262 (1992).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Feldstein et al., "Specific association between an endoribonucleolytic sequence from a satellite RNA and a substrate analogue containing a 2'-5' phosphodiester," Proc. Natl. Acad. Sci. USA 87:2623-2627 (1990).
Feldstein et al., "Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA," Gene 82:53-61 (1989).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Hampel et al., "The Hairpin Ribozyme," Methods: A Companion to Methods in Enzymology 5:37-42 (1993).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Haseloff and Gerlach, "Sequences required for self-catalysed cleavage of the satellite RNA of tobacco ringspot virus," Gene 82:43-52 (1989).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hegg and Fedor, "Kinetics and Thermodynamics of Intermolecular Catalysis by Hairpin Ribozymes," Biochemistry 34:15813-15828 (1995).
Hisamatsu et al., "Acquirement of hairpin ribozyme activity by the long substrate-binding site," Nucleic Acids Symp. Ser. 29:173-174 (1993).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1939).
Joseph et al., "Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates," Genes & Development 7:130-138 (1993).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kita et al., "Sequence and expression of rat ICAM-1," Biochem. Biophys. Acta 1131:108-110 (1992).
Komatsu et al., "Loop-Size Variation to Probe a Bent Structure of a Hairpin Ribozyme," J. Am. Chem. Soc. 116:3692-3696 (1994).
Komatsu et al., "Cross-ligation and exchange reaction catalyzed by hairpin ribozymes," Nucleic Acids Research 21:185-190 (1993).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992.
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Ortigao et al., "Antisense Effects of Oligodeoxynucleotides with Inverted Terminal Internucleotidic Linkages: A Minimal Modification Protecting Against Nucleolytic Degradation," Antisense Research and Development 2:129-146 (1992).
Perreault et al., "Mixed Deoxyribo- and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Simons et al., "ICAM, an adhesion ligand of LFA-1, is homologous to the neutral cell adhesion molecule NCAM," Nature 331:624-627 (1988).
Usman et al., "Automated Chemical Synthesis of Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3'-Half Molecule of an Escherichia coli Formylmethoionine tRNA," J. Am. Chem. Soc. 109:7845-7854 (1987).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
van Tol et al., "Evidence for Spontaneous Circle Formation in the Replication of the Satellite RNA of Tobacco Ringspot Virus," Virology 180:23-30 (1991).
von Ashen and Schroeder, "RNA as a Catalyst: Natural and Designed Ribozymes," BioEssays 15:299-307 (1993).
Woolf et al., "Specificity of Antisense Oligonucleotides in vivo," Proc. Natl. Acad. Sci. USA 89:7305-7309 (1992).
Yu et al., "A Hairpin Ribozyme Inhibits Expression of Diverse Strains of Human Immunodeficiency Virus Type 1," Proc. Natl. Acad. Sci. USA 90:6340-6344 (1993).
Zabner et al., "Adenovirus-Mediated Gene Transfer Transiently Corrects the Chloride Transport Defect in Nasal Epithelia of Patients with Cystic Fibrosis," Cell 75:207-216 (1993).
Zhou et al., "Synthesis of Functional mRNA in Mammalian Cells by Bacteriophage T3 RNA Polymerase," Mol. Cell. Biol. 10:4529-4537 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hairpin ribozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hairpin ribozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hairpin ribozymes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-885711

All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.