Hairpin peptides with a novel structural motif and methods...

Details Hairpin peptides with a novel structural motif and methods... Hairpin peptides with a novel structural motif and methods...

2005-07-05

2005-07-05

Wessendorf, T. D. (Department: 1639)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

C530S327000, C530S325000, C530S324000, C530S300000, C435S007100

Reexamination Certificate

active

06914123

ABSTRACT:
The invention is directed to a model system for structure-activity relationship analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising peptides with a novel “tryptophan zipper” scaffold (trpzip) that forms stable β-hairpin structure in solution. Methods of selecting and using such scaffold are provided herein, which are useful for mimicking native protein structures and interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.

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