Drug – bio-affecting and body treating compositions – Live hair or scalp treating compositions – Polymer containing
Patent
1993-08-04
1995-06-20
Lacey, David L.
Drug, bio-affecting and body treating compositions
Live hair or scalp treating compositions
Polymer containing
5303882, 5303893, 5303891, 436547, C07K 1604, G01N 33577
Patent
active
054259371
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to hair modifiers or hair damage protectives comprising an antibody having an immunological activity to keratins which constitute intermediate filaments which is characteristic of human hair.
The present invention also relates to hair cosmetics, more particularly, hair care products blended with an antibody having an immunological activity to a human hair keratinous protein which constitutes intermediate filaments.
Further, the present invention relates to a process for preparing an anti-hair keratin antibody having an immunological activity to hair keratinous proteins which constitute intermediate filaments, which antibody is useful as the above hair modifiers or hair damage protectives.
BACKGROUND ART
Generally, grooming and cosmetic treatments of hair by washing, brushing, heating with dryers, permanent-waving, hairdyeing or the like, substantially deteriorate and weaken the hair, and destroy the structure of the surface of the hair. Consequently, the hair dries and becomes brittle, split ends are formed or the hair may break, and lose its strength, while hair constituent proteins are eluted by treatments with shampoos, perm chemicals, hair dyes or the like and thus the proteins gradually disappear. Thus, with the elution of the proteins, the hair is made thinner and the likelihood of damage increases. The hair, once damaged, is unable to restore itself to its original state. Therefore, it is necessary to protect the hair from damage and in case of damage, to repair the damaged hair, in order to keep the hair beautiful and healthy.
For this purpose, hydrolysates of various proteins of natural origin or derivatives thereof have been used heretofore as a hair protective ingredient in hair care products such as shampoos, rinses, treating agents and the like. However, these substances have drawbacks such that they are readily washed away with water due to an extremely poor compatibility with hair, particularly because of their high water solubility, so that they have not been sufficiently effective.
On the other hand, U.S. Pat. No. 3,987,161 discloses a method for imparting improved body and set retention to the hair, using an antiserum which is prepared by using hair particles per se as an antigen. However, the antiserum prepared by this method binds to hair proteins so weakly that it has not been satisfactorily effective in preventing the elution of proteins from the hair or repairing the damaged hair.
Incidentally, hair consists of 3 types of cells: an outer cuticle wrapping and protecting the hair fiber, a cortex, i.e. the hair fiber itself, and a central medulla (hair medulla).
Among them, the cortex is composed mainly of three different types of proteins: fibrous "keratins which constitute filaments" (or .alpha.-keratinous fibrous proteins), non-fibrous "matrix proteins" and cell membrane peripheral proteins.
It has been known that the keratins which constitute intermediate filaments also exist in epidermis, nails, down, etc. are insoluble in water and solubilized in the presence of a denaturing agent, such as urea, SDS or the like, or a reducing agent, or by means of a chemical modification or the like. These proteins which originate from hair contain plenty of cystine and proline but little glycine, while those of an epidermis origin contain plenty of glycine and serine.
In the present invention, keratins which constitute intermediate filaments, which are obtained by solubilizing hair (nails or the like) under severe conditions as described above are employed, other than mere hair particles as described in the aforementioned U.S. Pat. No. 3,987,161.
It is known that an antibody to the keratins which constitute intermediate filaments is produced in the serum of animals such as rabbits, mice, guinea pigs or the like or in a culture solution of spleen cells of such animal origin (Baden: J. Jnvest. Dermatol., 75., 311, 1980; Cotton: Br. J. Dermatol., 3, 63, 1984; T. Tazawa: J. Jpn. Dermatol., 95, 157, 1985; Heid: Differentiation, 32, 101, 1986; etc.). Ho
REFERENCES:
patent: 3128230 (1964-04-01), Heinbach
patent: 3987161 (1976-10-01), Widder
"Comparison of Stratum Corneum and Hair Fibrous Proteins"; The Journal of Investigative Dermatology, 75:311-315, 1980; vol. 75 No. 4.
"Localization of Low-sulfur Keratin Proteins in the Wool Follicle Using Monoclonal Antibodies"; The Journal of Cell Biology; vol. 102, Apr. 1986, 1412-1418.
"Gamma Globulins of Bovine Lacteal Secretions"; Archives of Biochemistry and Biophysics; vol. 108, 1964, 230-239.
"Characterization of the Serum and Secretory Immune Systems of the Cow and Sheep"; The Journal of Immunology; vol. 103, No. 2 Aug. 1969, 334-344.
"Transfer of Immunoglobulins IgG, IgA and IgM to Lacteal Secretions in the Parturient Sow and Their Absorption by the Neonatal Piglet"; Biochemica et Biophysica Acta 181, 1969 381-392.
"Preparation of Bovine Immunoglobulins and Free Secretory Component and Their Specific Antisera"; Journal of Dairy Science vol. 55, No. 2, 151-164.
"The Nature of the Local Immune System of the Bovine Mammary Gland"; The Journal of Immunology, vol. 118, No. 2, Feb. 1977, 461-465.
"A Procedure for Preparing Immunoglobulin G from Human and Monkey Blood"; Transfusion 6, 146-149, 1966.
"Human Gamma Globulin Fractionation on Anion Exchange Cellulose Columns"; The Journal of Biological Chemistry; vol. 234, No. 10 Oct. 1959, 2645-2651.
"Immunoglobulin IgA in Bovine Serum and External Secretions"; Biochimica Et Biophysica Acta; 214 (1970) 107-116.
"Substitution of Egg Yolk for Serum in Indirect Fluorescence Assay for Rous Sarcoma Virus Antibody"; Proc. Soc. Exptl. Bio. Med., 126, (1967) 312-315.
"Antibodies to Proteins from Yolk of Immunized Hens"; Immunological Communications, 9(5), (1980), 495-514.
"Immunoperoxidase Anti-Keratin Staining of Epidermal and Pilar Cysts"; British Journal of Dermatology; (1984), III, 63-68.
"The Complement of Native .alpha.-keratin Polypeptides of Hair-Forming Cells: A Subject of Eight Polypeptides that Differ From Epithelial Cytokeratins"; Differentiation (1968) 32:101-119.
Virtanen, I. et al., Ann New York Acad. Sci., 455:635-648, 1985.
Ebina Takusaburou
Hirano Makoto
Horikoshi Toshio
Minamino Hiromi
Murakami Umeji
Kanebo Ltd.
Lacey David L.
Loring Susan A.
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