Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-04-08
1993-05-25
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142232, 514716, 514727, 514740, 514742, 514523, A61K 3154
Patent
active
052140415
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a novel hair revitalizing tonic composition, and more specifically, it relates to a hair revitalizing tonic composition comprising an amine oxide, a compound having a calmodulin inhibitory activity and/or a compound having an activity as a calcium antagonist.
BACKGROUND ART
It is generally believed that baldness and a falling-out of hair are caused by (1) an activation of androgens in organs such as the hair roots and sebaceous glands, (2) a lowering of blood flow to the hair follicles, (3) an abnormality of the scalp due to an excessive secretion of sebum, formation of peroxides, or propagation of bacteria or the like, (4) heredodiathesis, (5) neuroses due to stress or the like, (6) side effects of diseases, and (7) aging.
Accordingly, conventional hair revitalizing tonic compositions generally contain a compound by which the above-mentioned causes are eliminated or alleviated. For example, a compound capable of inhibiting the activation of androgens or a compound capable of increasing blood flow to the hair follicles is contained in the hair tonic.
Nevertheless, the mechanisms of loss and regrowth of hair are very complicated, and thus it is impossible to satisfactorily prevent baldness and a falling-out of hair simply by inhibiting the activation of androgens or by increasing the amount of blood flow to the hair follicles.
DISCLOSURE OF INVENTION
Therefore, an object of the present invention is to solve the above-mentioned problems of the conventional hair revitalizing tonic compositions and to provide a hair revitalizing tonic composition which provides an excellent effect of preventing hair loss, and further, of invigorating hair growth.
Other objects and advantages of the present invention will be apparent from the following description.
In accordance with the present invention, there is provided a hair revitalizing tonic compositions comprising (i) an amine oxide and (ii) at least one compound selected from compounds having a calmodulin inhibitory activity and compounds having an activity as a calcium antagonist.
BEST MODE OF CARRYING OUT THE INVENTION
The present inventors carried out research in an attempt to find a compound which would effectively prevent hair loss, and further, having an excellent hair invigorating activity, and as a result, found that a hair revitalizing tonic composition comprising an amine oxide effectively prevents hair loss, and further, invigorates the hair growth. The hair revitalizing tonic composition based on this invention is described in the specification of Japanese Patent Application No. 63-6233. The present inventors then made a further study of the above-mentioned amine oxide, and as a result, found that the effects of preventing hair loss and of invigorating hair growth can be enhanced through the incorporation of the amine oxide in combination with a specific substance. The present invention was completed on the basis of this finding.
Examples of the amine oxide usable in the present invention include the following compounds.
(1) A dimethylalkylamine oxide having the general formula (A): ##STR1## wherein R.sup.1 represents a straight-chain or branched alkyl or alkenyl group having 8 to 24 carbon atoms. Specific examples thereof are dimethyllaurylamine oxide, dimethylstearylamine oxide.
(2) A methyldialkylamine oxide having the general formula (B): ##STR2## wherein R.sup.2 and R.sup.3 each independently represent a straight-chain or branched alkyl or alkenyl group having 6 to 18 carbon atoms. Specific examples thereof are didecylamine oxide and didodecylamine oxide.
(3) A dihydroxyethylalkylamine oxide having the general formula (C): ##STR3## wherein R.sup.4 represents a straight-chain or branched alkyl or alkenyl group having 8 to 24 carbon atoms. Specific examples thereof are dihydroxyethyllaurylamine oxide.
(4) A dimethylalkylpolyoxyethyleneamine oxide having the general formula (D): ##STR4## wherein R.sup.5 represents a straight chain or branched alkyl or alkenyl group having 8 to 24 carbon atoms and
REFERENCES:
patent: 4973474 (1990-11-01), Hocquaux et al.
patent: 4985425 (1991-01-01), Chiba et al.
Patent Abstracts of Japan, vol. 4, No. 85, Jun. 18, 1980.
Patent Abstracts of Japan, vol. 13, No. 569, Dec. 15, 1989 & JP-A-1 238 515, Sep. 22, 1989.
Fujii Seishiro
Ishino Akihiro
Miyazawa Kiyoshi
Shiseido Company Ltd.
Tsung Fred
Waddell Frederick E.
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