Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1988-11-29
1990-10-09
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 944, 424 72, 8401, 8406, A61K 709, A61K 713, A45D 704
Patent
active
049619250
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a hair preparation composition characterized in that a dielectron reducing oxidase utilizing oxygen as an acceptor is incorporated as an active ingredient.
BACKGROUND ART
Heretofore, with oxidation hair dyes, for oxidation polymerization of an oxidation dye and in order to bleach hair, hydrogen peroxide, sodium perborate, sodium percarbonate, etc. are used as the oxidizing agent.
Further, in general, for performing a permanent wave, there is employed a method which comprises reducingly cutting the S-S bond in hair with a first solution containing a reducing agent such as thioglycolic acid, cysteine, etc. as a main component and thereafter oxidizingly fixing this hair with a second solution containing an oxidizing agent such as sodium bromate, sodium perborate, hydrogen peroxide etc. as a main component.
However, the use of these oxidizing agents has a disadvantage that they are apt to damage hair and skin.
DISCLOSURE OF THE INVENTION
The present invention is characterized by activating oxygen in air with an oxidase and effectively employing its oxidizing power in the oxidizing course needed for the product.
A first object of the present invention is to provide a hair preparation composition which has a satisfactory effect with a mild oxidizing effect.
A second object of the present invention is to provide a hair preparation composition having an oxidizing function which is low in skin irritation and hardly damages hair and skin, such as an oxidation hair dye, an oxidation agent composition for permanent waving preparation, a bleaching agent for hair or body hair on hands and feet, etc.
The present invention is described in more detail below.
The present invention provides a hair preparation composition which contains at least one dielectron reducing oxidase utilizing oxygen as an acceptor.
The enzyme used in the present invention is a dielectron reducing oxidase utilizing oxygen as an acceptor, and mention is made of, for example, pyranose oxidase (hereinafter referred to as PROD), glucose oxidase (hereinafter referred to as GOD), glycerol oxidase, lactic acid oxidase, pyruvic acid oxidase, uricase, etc.
In the present invention, these enzymes are used either alone or as a combination of two or more thereof.
Further, in order that certain enzymes suitable for the present invention function, cofactors as required. For example, it is known that as cofactors, flavin adenine dinucleotide (hereinafter referred to as FAD) and iron ions are necessary for PROD; FAD and iron ions for GOD; and FAD for pyruvic acid oxidase.
These cofactors are generally contained as impurities in enzymes, and therefore, where the enzyme is described in the present specification, it is understood that it also contains the necessary cofactors unless otherwise specified.
The present invention further provides a hair preparation composition which contains the above-described oxidase and a donor of said enzyme.
The donor varies depending on the enzyme, and for example, there are used D-glucose, L-sorbose and D-xylose for PROD; D-glucose for GOD; glycerol, dihydroxyacetone for glycerol oxidase; lactic acid and its salts for lactic acid oxidase; pyruvic acid and its salts for pyruvic acid oxidase; and uric acid and its salts for uricase.
The amount of the enzyme incorporated is 1 unit/100 g to 1.times.10.sup.8 units/100 g, preferably 1.times.10.sup.2 units/100 g to 1.times.10.sup.5 units/100 g, as the concentration in actual use on hair.
The amount of the donor is 0.01% by weight to 60% by weight, preferably 1% by weight to 35% by weight, as the concentration in actual use on hair.
In the present invention, where D-glucose is used as the donor, PROD is preferred as the enzyme. This is because PROD acts on both .alpha.-type and .beta.-type of D-glucose.
Where GOD is used, it is preferred to use it in combination with mutarotase. This is because mutarotase performes rearrangement of D-glucose from .alpha.-type to .beta.-type.
It is known that the activity of enzymes can be maintained and
REFERENCES:
patent: 3251742 (1966-05-01), Soloway
Hagino Hiroshi
Sakato Kuniaki
Tsujino Yoshio
Yokoo Yoshiharu
Cashion Jr. Merrell C.
Kyowa Hakko Kogyo Co. Ltd.
Rucker Susan S.
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