Hair keratin-associated proteins

Details Hair keratin-associated proteins Hair keratin-associated proteins

2007-06-05

2007-06-05

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S328000, C530S357000, C424S070100

Reexamination Certificate

active

10846374

ABSTRACT:
The present invention relates to provide a protein group binding to keratin which is the major component of body hair, or genes encoding the same, particularly to keratin-associated proteins (KAP) which bind specifically and strongly to hair keratin or genes encoding the same. The base sequence of eurochromtic region of approximately 33.5 Mb of human chromosome 21 was determined, a dot-matrix analysis of the base sequence of the long arm region of chromosome 21 (21q22.3) was carried out, homology search was made to low frequency repetitive sequences and 16 KAP genes being expressed only in hair root cells were found. Moreover, the high frequency repetitive sequences present in the sequence spanning for approximately 1 Mb between CLDN8 gene and TIAM1 gene in the long arm region of chromosome 21(21q22.11) were masked, the presence or absence of short low frequency repetitive sequence was searched, and 22 KAP genes were found. Moreover, a group of functional peptide was designed from the above mentioned KAPs.

REFERENCES:
Zhumabaeva et al., “Cloning and structural characteristics of human hair keratin genes rich in sulfur,” Mol Biol 26:813-820, 1992.
Zhumabaeva et al., GenBank Record No. CAA44938, corresponds to Mol Biol 26:813-820, 1992.
Rogers et al., “Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21,” J Biol Chem 276(22):19440-19541, 2001.
Rogers et al., GenBank Record No. NP—114163, keratin associated protein 1.5 [Homo sapiens], corresponds to J Biol Chem 276(22):19440-19451, 2001.
Aoki et al., GenBank Record No. BAB61026, direct submission, Jun. 21, 2001.
Adachi et al., submission to EMBL/GenBank/DDBJ databases in Jul. 2000, released as Uniprot database record No. Q9D3H7 on Jun. 1, 2001.
Michael A. Rogers et al., “Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Gense Embedded in the Type 1 Keratin Gene Domain on Chromosome 17q12-21*”, The Journal of Biological Chemistry, vol. 276, No. 22, Issue of Jun. 1, pp. 19440-19451, 2001.
M. Hattori et al., “The DNA sequence of human chromosome 21”, Nature, vol. 405, pp. 311-319, May 18, 2000.

Affiliated with

Also associated with

Rating

Hair keratin-associated proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hair keratin-associated proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hair keratin-associated proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3880025