Haemopoietin receptor and genetic sequences encoding same

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600

Reexamination Certificate

active

06870031

ABSTRACT:
The present invention is directed to a novel haemopoietin receptor or a derivative thereof and to genetic sequences encoding same. The receptor molecule and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor. The present invention particularly relates to a receptor for leptin.

REFERENCES:
patent: 5869610 (1999-02-01), Snodgrass et al.
X. X. Du, et al. (1994), “Interlueken-11: A Multifunctional Growth Factor Derived From the Hematopoietic Microenvironment”,Blood, 83: pp. 2023-2030.
Y.C. Yang, et al. (1992), “Interleukin-11 and Its Receptor”,Biofactors, 4: pp. 15-21.
S.R. Paul, et al. (1990), “Molecular Cloning of a cDNA Encoding Interleukin 11, a Stromal Cell-Derived Lymphpoietic and Hematopoietic Cytokine”,Proc. Natl. Acad. Sci. USA, 87: pp. 7512-7516.
M. Musashi, et al. (1991), “Synergistic Interactions Between Interleukin-11 and Interleukin-4 in Support of Proliferation of Primitive Hematopoietic Progenitors of Mice”,Blood, 78: pp. 1448-1451.
K.R. Schibler, et al. (1992), “Effect of Interleukin-11 on Cycling Status and Clonogenic Maturation of Fetal and Adult Hematopoietic Progenitors”,Blood, 4: pp. 900-903.
K. Tsuji, et al. (1992), “Ehancement of Murine Hematopoiesis by Synergistic Interactions Between Steel Factor (ligand for c-kit), Interleukin-11, and Other Early Acting Factors in Culture”,Blood, 79: pp. 2855-2860.
Samuel A. Burstein, et al. (1992), “Leukemia Inhibitory Factor and Interleukin-11 Promote Maturation of Murine and Human Megakaryocytes in Vitro”,J. Cell. Physiol, 153: pp. 305-312.
Giao Hangoc, et al. (1993), “In Vivo Effects of Recombinant Inerleukin-11 on Myelopoiesis in Mice”,Blood, 81: pp. 965-972.
Masanao Teramura, et al. (1992), “Interleukin-11 Enhances Human Megakaryocytopoiesis in Vitro”,Blood, 79: pp. 327-331.
Yuji Yonomura, et al., (1992), “Synergistic Effects of Interleukin 3 and Interleukin-11 on Murine Megakaryopoiesis in Serum-free Culture”,Exp. Hematol, 20: pp. 1011-1016.
Heinz Baumann, et al., (1991), “Interleukin-11 Regulates the Hepatic Expression of the Same Plasma Protein Genes as Interleukin-6”,J. Biol. Chem., 266: pp. 20424-20427.
Ichiro Kawashima, et al. (1991), “Molecular Cloning of cDNA Encoding Adipogenesis Inhibitory Factor and Identity with Interleukin-11”,Febs. Lett., 283: pp. 199-202.
D.C. Keller, et al. (1993), “Interleukin-11 Inhibits Adipogenesis and Stimulates Myelopoiesis in Human Long-Term Marrow Cultures”,Blood, 82: pp. 1428-1435.
J. Sambrook, et al., (1989), “Molecular Cloning”,A Laboratory Manual Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Douglas J. Hilton, et al. (1994), “Cloning of a Murine IL-11 Receptor α-chain; Requirement for gp130 for High Affinity Binding and Signal Transduction”,EMBO Journal, 13: pp. 4765-4777.
Da-Wei Gong, et al. (1996), “Genomic Structure and Promoter Analysis of the Human obese Gene”,J. Boil. Chem., 271: pp. 3971-3974.
Seiichi Mizushima, et al. (1990), “pEF-BOS, a Powerful Mammalian Expression Vector”, Nucleic Acids Research, 18: pp. 5322.
Nicos A. Nicola (1996), “Molecular Cloning of Two Novel Transmembrane Ligands for EphRelated Kinases (LERKS) that are Related to LERK-2”,Growth Factors, 13: pp. 141-149.
Douglas J. Hilton, et al. (1992), “Kinetic Analyses of the Binding of Leukemia Inhibitory Factor to Receptors on Cells and Membranes and in Detergent Solution”,J. Biol. Chem., 267: 10238-10247.
George Scatchard (1949), “The Attractions of Proteins for Small Molecules and Ions”,Ann. N.Y. Acad. Sciences, 51: 660-672.
Unit 3.3.1 (1995), “Mapping by Partial Endonuclease Digestions”,Current Protocols in Molecular Biology.
Marvin B. Shapiro, et al. (1987), “RNA Splice Junctions of Different Classes of Eukaryotes: Sequence Statistics and Functional Implications in Gene Expression”,Nucleic Acids Research, 15: 7155-7174.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Haemopoietin receptor and genetic sequences encoding same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Haemopoietin receptor and genetic sequences encoding same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Haemopoietin receptor and genetic sequences encoding same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3417613

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.