Haemophilus influenzae type IV pili

Details Haemophilus influenzae type IV pili Haemophilus influenzae type IV pili

2011-02-22

2011-02-22

Swartz, Rodney P. (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C424S184100, C424S185100, C424S242100, C424S256100, C424S278100

Reexamination Certificate

active

07893237

ABSTRACT:
The invention described herein relates to aHaemophilus influenzae(H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeableH. influenzae(NTHi) and fromH. influenzaestrains a, b, c, e and f. The invention provides isolatedH. influenzaepilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response toH. influenzaeand methods of treating and preventingH. influenzaerelated pathological conditions.

REFERENCES:
patent: 6268171 (2001-07-01), Meyer et al.
patent: 6506581 (2003-01-01), Fleischmann et al.
patent: WO 03/078453 (2003-09-01), None
Anderson et al.,J. Clin. Invest., “Human Serum Activities AgainstHemophilus influenzae, Type b”, 51:31-38 (1972).
Bakaletz et al.,Infect. Immun., “Frequency of Fimbriation of NontypableHaemophilus influenzaeand Its Ability To Adhere to Chinchilla and Human Respiratory Epithelium”, 56:331-335 (1988).
Bakaletz et al.,J. Infect. Dis., “Modeling Adenovirus Type 1-Induced Otitis Media in the Chinchilla: Effect on Ciliary Activity and Fluid Transport Function of Eustachian Tube Mucosal Epithelium”, 168:865-872 (1993).
Bakaletz and Holmes,Clin. Diagn. Lab. Immunol., “Evidence for Transudation of Specific Antibody in the Middle Ears of Parenterally Immunized Chinchillas after an Upper Respiratory Tract Infection with Adenovirus”, 4:223-225 (1997).
Bakaletz et al.,Vaccine, “Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeableHaemophilus influenzaein the chinchilla” 15:955-961 (1997).
Bakaletz et al.,Infect. Immun., “Protection against Development of Otitis Media Induced by NontypeableHaemophilus influenzaeby Both Active and Passive Immunization in a Chinchilla Model of Virus-Bacterium Superinfection”, 67:2746-2762 (1999).
Baldwin,Am. J. Otol., “Effects of Otitis Media on Child Development”, 14:601-604 (1993).
Bardy,Microbiology, “Prokaryotic Motility Structures”, 149:295-304 (2003).
Bendler and Goodgal,J. Microbiol., “The Type b Capsulation Locus ofHaemophilus influenzae: Map Location and Size”, 70:411-422 (1972).
Berman et al.,Pediatrics, “Theoretical Cost Effectiveness of Management Options for Children with Persisting Middle Ear Effusions”, 93(3):353-363 (1994).
Black et al.,Pedriatr. Infect. Dis. J., “Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children”, 19:187-195 (2000).
Bright et al.,Am. J. Public Health, “The Prevalence of Tympanostomy Tubes in Children in the United States, 1988”, 83(7):1026-1028 (1993).
Cimons,ASM News, “Lurid Reports Obscure Reality of Strep A Outbreaks”, 60:527-530 (1994).
Coleman et al.,Inf. and Immunity, “Molecular Cloning, Expression, and Sequence of the Pilin Gene from NontypeableHaemophilus influenzaeM37” 59(5):1716-1722 (1991).
Coleman et al.,J. Clin. Micro., “Chemically Defined Media for Growth ofHaemophilus influenzaeStrains”, 41:4408-4410 (2003).
Daines et al.,J. Med. Microbiol., “Haemophilus influenzaeRd KW20 has virulence properties”, 52:277-282 (2003).
Darzins and Russell,Gene, “Molecular genetic analysis of type-4 pilus biogenesis and twitching motility usingPseudomonas aeruginosaas a model system—a review”, 192:109-115 (1997).
DeMaria et al.,Infect. Immun., “Immunization with Outer Membrane Protein P6 from NontypeableHaemophilus influenzaeInduces Bactericidal Antibody and Affords Protection in the Chinchilla Model of Otitis Media”, 64:5187-5192 (1996).
Doughty et al.,Vet. Microbiol., “The type 4 fimbrial subunit gene ofPasteurella multocida”, 72:79-90 (2000).
Dougherty and Smith,Microbiology, “Identification ofHaemophilus influenzaeRd transformation genes using cassette mutagenesis”, 145(2):401-409 (1999).
Ehrlich et al.,JAMA, “Mucosal Biofilm Formation on Middle-Ear Mucosa in the Chinchilla Model of Otitis Media”, 287(13):1710-1715 (2002).
Eskola and Kilpi,Pedriatr. Infect. Dis. J., “Potential of bacterial vaccines in the prevention of acute otitis media”, 19:S72-78 (2000).
Eskola et al.,N. Engl. J. Med., “Efficacy of a Pneumococcal Conjugate Vaccine Against Acute Otitis Media”, 344:403-409 (2001).
Fleischmann et al.,Science, “Whole-Genome Random Sequencing and Assembly ofHaemophilus influenzaeRd”, 269:496-512 (1995).
Friedrich et al.,Applied and Environmental Microbiology“Molecular Analyses of the Natural Transformation Machinery and Identification of Pilus Structures in the Extremely Thermophilic BacteriumThermus thermophilusStrain HB27”, 68(2):745-755 (2002).
Friedrich et al.,Appl. Environ. Microbiol., “Pilin-Like Proteins in the Extremely Thermophilic BacteriumThermus thermophilusHB27:Implication in Competence for Natural Transformation and Links to Type IV Pilus Biogenesis”, 69:3695-3700 (2003).
Fussenegger et al.,Gene, “Transformation competence and type-4 pilus biogenesis inNeisseria gonorrhoeae-a review”, 192:125-134 (1997).
Genbank Accession No. U32715, “Haemophilus influenzaeRd KW20 section 30 of 163 of the complete genome” (Aug. 9, 1995).
Gilsdorf et al.,Pediatr. Res., “Role of Pili inHaemophilus influenzaeAdherence to, and Internalization by, Respiratory Cells”, 39:343-348 (1996).
Gilsdorf et al.,Infect. Immun., “Role of Pili inHaemophilus influenzaeAdherence and Colonization”, 65:2997-3002 (1997).
Holmes et al.,Microb. Pathog., “Adherence of non-typeableHaemophilus influenzaepromotes reorganization of the actin cytoskeleton in human or chinchilla epithelial cells in vitro”, 23:157-166 (1997).
Hunter et al.,Ann. Otol. Rhinol. Laryngol. Suppl., “Identification of Hearing Loss in Children with Otitis Media”, 163:59-61 (1994).
Jesaitis et al.,J. Immunol., “Compromised Host Defense onPseudomonas aeruginosaBiofilms: Characterization of Neutrophil and Biofilm Interactions”, 171:4329-4339 (2003).
Kaplan et al.,Pediatr. Infect. Dis. J., “Overall cost in the treatment of otitis media”, 16:S9-11 (1997).
Karudapuram et al.,J. Bacteriology, “TheHaemophilus influenzae dprABCGenes Constitute a Competence-Inducible Operon That Requires the Product of thetfoX(sxy) Gene for Transcriptional Activation,” 179(15):4815-4820 (1997).
Keizer et al.,J. Biol. Chem., “Structure of a Pilin Monomer fromPseudomonas aeruginosa”, 276:24186-24193 (2001).
Kennedy et al.,Infect. Immun., “Passive Transfer of Antiserum Specific for Immunogens Derived from a NontypeableHaemophilus influenzaeAdhesin and Lipoprotein D Prevents Otitis Media after Heterologous Challenge”, 68:2756-2765 (2000).
Klausen et al.,Mol. Microbiol., “Biofilm formation byPseudomonas aeruginosawild type, flagella and type IV pili mutants”, 48:1511-1524 (2003).
Klausen et al.,Mol. Microbiol., “Involvement of bacterial migration in the development of complex multicellular structures inPseudomonas aeruginosabiofilms”, 50:61-68 (2003).
Klein,Pedriatr. Infect. Dis. J., “Role of nontypeableHaemophilus influenzaein pediatric respiratory tract infections,” 16:S5-8 (1997).
Klein,Vaccine, “The Burden of Otitis Media”, 19(Suppl. 1):S2-S8 (2001).
Kyd et al.,Infect. lmmun., “Potential of a Novel Protein, OMP26, from NontypeableHaemophilus influenzaeTo Enhance Pulmonary Clearance in a Rat Model”, 66:2272-2278 (1998).
Mason et al.,Infect. Immun., “NontypeableHaemophilus influenzaeGene Expression Induced In Vivo in a Chinchilla Model of Ot

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