Haemophilus influenzae type b oxidized polysaccharide-outer memb

Details Haemophilus influenzae type b oxidized polysaccharide-outer memb Haemophilus influenzae type b oxidized polysaccharide-outer memb

1989-02-21

1993-03-09

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

530324, 530395, 530405, 530409, 530412, 530413, 536 187, A61K 3902, C07K 300

Patent

active

051925400

ABSTRACT:
Immunogenic conjugates of a 38,000 daltons or 40,000 daltons outer membrane protein of H. influenzae type b and oxidized polyribosyl-ribitol-phosphate polysaccharide fragments of H. influenzae type b are disclosed. Vaccines containing the conjugates are disclosed as useful in immunizing against H. influenzae type b caused disease. Method for isolating and purifying the 38,000 daltons and 40,000 daltons outer membrane proteins and for preparing the oxidized polyribosyl-ribitol-phosphate polysaccharide fragments are also disclosed.

REFERENCES:
patent: 4220717 (1980-09-01), Kuo
Munson et al, J. Clin. Invest. vol. 72, pp. 677-684, 1983.
Vachon et al, J. Bacteriol., vol. 162, pp. 918-924, 1985.

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