Haemophilus influenzae type b and pertussis outer membrane compo

Details Haemophilus influenzae type b and pertussis outer membrane compo Haemophilus influenzae type b and pertussis outer membrane compo

1981-11-19

1984-10-02

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, A61K 3910, A61K 39102

Patent

active

044747586

ABSTRACT:
A combined vaccine for eliciting polyribosyl ribitol phosphate (PRP) antibody formations in warm-blooded animals has been invented. The combined vaccine comprises the capsular polysaccharide PRP isolated and purified from Haemophilus influenzae type b and antigens isolated and purified from an outer membrane component of Bordetella pertussis.
A method for inducing active immunization in warm-blooded animals against systemic infection caused by the pathogen H. influenzae type b has also been invented. The method comprises administering an immunogenic amount of a combined vaccine comprising the capsular polysaccharide PRP isolated and purified from H. influenzae type b and antigens isolated and purified from an outer membrane component of B. pertussis.

REFERENCES:
patent: 3395219 (1968-07-01), Millman
patent: 3465078 (1969-09-01), Spiesel
patent: 4196192 (1980-04-01), Kuo
patent: 4220717 (1980-09-01), Kuo
King, S., et al., Lancet, Oct. 3, 1981, (2)8249, pp. 705-709.

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