Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1989-11-09
1992-05-05
Rosen, Sam
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
435169, 435170, 435171, 4351721, 435820, 435851, 435 711, 435 712, 530333, 530345, 530350, 530806, 530808, 530825, C07K 1300
Patent
active
051109085
ABSTRACT:
Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of puiification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides and proteins in hybridization assays is also described.
REFERENCES:
Murphy, T. F. et al., Infection and Immunity, vol. 54, No. 3, Dec. 1986, pp. 774-779.
Murphy, T. F. et al., J. Clin. Invest., vol. 78, Oct. 1986, pp. 1020-1022.
Burans, J. P. et al., Infection and Immunity, vol. 41, No. 1, Jul. 1983, pp. 285-293.
Anderson et al., 1972, J. Clin. Invest., 51:31-38.
Barenkamp et al., 1982, Infect. Immun., 36:535-540.
Barnekamp et al., 1981, J. Infect. Dis., 143:668-676.
Coulton et al., 1983, Can. J. Microbiol., 29:280-287.
Granoff et al., 1986, J. Infect. Dis., 153:448-461.
Gulig et al., 1982, Infect. Immun., 37:82-88.
Hansen et al., 1982, Lancet, Feb. 12, 1982, 366-368.
Lam et al., 1980, Current Microbiol., 3:359-364.
Loeb et al., 1982, Infect. Immun., 37:1032-1036.
Loeb et al., 1981, J. Bacteriol., 145:596-605.
Loeb et al., 1980, Infect. Immun., 30:709-717.
Munson et al., 1984, Abstracts of the ICAAC: 234; No. 829.
Murphy et al., 1984, Abstracts of the ICAAC 234; No. 831.
Murphy et al., 1983, J. Infect. Dis., 147:838-846.
Shenep et al., 1983, Infect. Immun., 42:257-263.
Solotorovsky et al., 1978, in CRC Critical Reviews in Microbiology, pp. 1-32.
van Alphen et al., 1983, FEMS Microbiol. Lett., 18:189-195.
van Alphen et al., 1983, J. Bacteriol., 155:878-885.
Wallace et al., 1981, J. Infect. Dis., 144:101-106.
Deich Robert A.
Green Bruce
Zlotnick Gary
Baldwin Geraldine F.
Gordon Alan M.
Praxis Biologics, Inc.
Rosen Sam
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