Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2007-12-20
2010-10-12
Graser, Jennifer E (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S251100, C424S185100, C424S190100, C424S200100, C530S350000
Reexamination Certificate
active
07811590
ABSTRACT:
This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeableH. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment ofHaemophilus influenzaeinfection.
REFERENCES:
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Bakaletz, et al., “Protection Against Development of Otitis Media Induced by NontypeableHaemophilus influenzaeby Both Active and Passive Immunization in a Chinchilla Model of Virus-Bacterium Superinfection”.Infection and Immunity, 67(6): 2746-2762 (1999).
Webb, et al., “Secondary Structure and Molecular Analysis of Interstrain Variability in the P5 Outer-Membrane Protein of Non-TypeableHaemophilus influenzaeIsolated from Diverse Anatomical Sites”.Journal of Medical Microbiology, 47(12): 1059-1067 (1998).
Munson et al.Infect. Immun., 61(9): 4017-4020 (1993).
Mikayama et al.Proc. Natl. Acad. Sci. USA, 90: 10056-10060 (1993).
Rudinger et al.Peptide Hormones Biol. Council, 1-7 (1976).
Bakaletz Lauren O.
Berthet Francois-Xavier Jacques
Denoel Philippe
Poolman Jan
Thonnard Joelle
Calfee Halter & Griswold LLP
GlaxoSmithKline
Graser Jennifer E
The Ohio State University Research Foundation
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