Haemophilus influenzae B polysaccharide-diptheria toxoid conjuga

Details Haemophilus influenzae B polysaccharide-diptheria toxoid conjuga Haemophilus influenzae B polysaccharide-diptheria toxoid conjuga

1985-01-16

1987-02-17

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424 88, 424 92, C08B 3700, A61K 39102

Patent

active

046440593

ABSTRACT:
A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, is prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.

REFERENCES:
patent: 4196192 (1980-04-01), Kuo
patent: 4220717 (1980-09-01), Kuo
patent: 4264764 (1981-04-01), Kniskern et al.

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