Haemophilus influenzae b polysaccharide-diphtheria toxoid conjug

Details Haemophilus influenzae b polysaccharide-diphtheria toxoid conjug Haemophilus influenzae b polysaccharide-diphtheria toxoid conjug

1982-01-06

1985-01-29

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112R, 536 11, 424 88, A61K 39102, C07G 700

Patent

active

044965389

ABSTRACT:
A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.

REFERENCES:
patent: 4196192 (1980-04-01), Kuo
patent: 4210641 (1980-07-01), Brossard et al.
patent: 4220717 (1980-09-01), Kuo
Schneerson et al., J. Exp. Med., vol. 152, No. 2, pp. 361-376, 1980.
Anderson et al., J. Infect. Dis., vol. 146, No. 6, pp. 530-538, 1981.

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