Haemophilus adhesion proteins

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241851, 4242561, 530350, A61K 3902

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active

060600594

ABSTRACT:
The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

REFERENCES:
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van Ham, S. M., et al., "Contribution of the Major and Minor Subunits to Fimbria-Mediated Adherence of Haemophilus influenzae to Human Epithelial Cells and Erythrocytes," Infection and Imuunity, 63(12):4883-4889 (1995).
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Barenkamp, S.J., et al., "Cloning, Expression, and DNA Sequence Analysis of Genes Encoding Nontypeabale Haemophilus influenzae High-Molecular-Weight Surface-Exposed Proteins Related to Filamentous Hemagglutinin of Bordetella pertussis," Infection and Immunity, 60(4):1302-1313 (1992).
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St. Geme, J.W., et al., "Evidence that Surface Fibrils Expressed by Haemophilus influenzae type b Promote Attachment to Human Epithelial Cells," Molecular Microbiology, 15(1):77-85 (1995).
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Barenkamp, S.J., et al., "Genes Encoding High-Molecular-Weight Adhesion Proteins of Nontypeable Haemophilus influenzae Are Part of Gene Clusters," Infection and Immunity, 62(8):3320-3328 (1994).
Barenkamp, S.J., et al., "Identification of a Second Family of High Molecular Weight Adhesion Proteins Expressed by Nontypeable Haemophilus influenzae (NTHl)" 105th Annual Meeting of the American Pediatric Society and the 64th Ammual Meeting of the Society for Pediatric Research, San Diego:USA, May 7-11, Abstract No. 1003, Pediatric Research, 37 (4 part 2), p. 170A (1995).
Fleischmann, R.D. et al., "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd," Science, 269 (5223):496-498, 507-512 (1995).
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