Haemocoagulase

Details Haemocoagulase Haemocoagulase

2011-08-09

2011-08-09

Naokes, Suzanne M. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Reexamination Certificate

active

07993893

ABSTRACT:
The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more nucleotide based on the said nucleotide sequence with an equivalent function. The said haemocoagulase has amino acid sequence shown by SEQ ID NO: 2. Haemocoagulase of the present invention has an obvious hemostatic effect, a broad effective dose range, safe and reliable application, which creates good conditions for the development of genetic engineering products of recombinant haemocoagulase in the future.

REFERENCES:
patent: 1534093 (2004-10-01), None
patent: WO 99/29838 (1999-06-01), None
patent: 2005017139 (2005-02-01), None
Castro et al., “Snake venom thrombin-like enzymes: from reptilase to now”, Cell. Mol. Life Sci., 2004, vol. 61, pp. 843-856.
Nobuyuki Itoh et al “Molecular Cloning and Sequence Analysis of cDNA for Batroxobin, a Thrombin-like Snake Venom Enzyme” J. Biol. Chem. Mar. 5, 1987, vol. 262, No. 7, pp. 3132-3135.
Nobuyuki Itoh et al “Organization of the Gene for Batroxobin, a Thrombin-like Snake Venom Enzyme” J. Biol. Chem. Jun. 5, 1988, vol. 263, No. 16, pp. 7628-7631.
Nobuyuki Itoh et al “The complete nucleotide sequence of the gene for batroxobin, a thrombin-like snake venom enzyme” Nucleic Acids Res. Nov. 11, 1988, Vo. 16, No. 21, pp. 10377-10378.

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