Haematopoietic cytokine Epstein Barr virus-induced protein

Details Haematopoietic cytokine Epstein Barr virus-induced protein Haematopoietic cytokine Epstein Barr virus-induced protein

1996-07-19

1998-11-03

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 697, 435 712, 4351723, 435325, 4352523, 4353201, 536 234, 536 235, 536 2431, A61K 3819, C07K 1452

Patent

active

058304517

ABSTRACT:
A novel heterodimeric haematopoietic cytokine formed from the Epstein Barr Virus-Induced protein 3 (EBI3) and the p35 subunit of Interleukin-12 (IL12) is disclosed. Substantially pure preparations of this EBI3/p35 cytokine, and antibodies thereto, are provided. In addition, isolated nucleic acids encoding the EBI3/p35 cytokine, and recombinant host cells transformed with these nucleic acids, are also provided. Methods of treating patients, using the EBI3/p35 cytokine or nucleic acids encoding the cytokine, are disclosed. The invention also provides for diagnostic assays for detecting pregnancy or threatened spontaneous abortion using antibodies to the cytokine.

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