Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-01-10
1999-12-14
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 21, 800 22, 800 25, 800 11, 800 3, 435455, 435463, 4353201, 435325, 435 691, 435 912, 435 4, 424 921, C12N 1509, C12N 1563, C12N 1500, C12N 500
Patent
active
060020660
ABSTRACT:
A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.
REFERENCES:
Bradley et al., Biotechnology, vol. 10, pp. 534-539,. May 1992.
Seamark, Reproduction, Fertility and Development, vol. 6, pp. 653-657, 1994.
Mullins et al., Journal of Clinical Investigations, vol. 98, pp. S37-S40, 1996.
Capecchi, Scientific American, vol. 270, pp. 34-41, Mar. 1994.
Hermel et al., Immunogenetics, vol. 42, pp. 136-142, 1995.
Cho et al., Nature, vol. 353, pp. 573-576, Abstract only, 1991.
Grusby et al., Science, vol. 253, pp. 1417-1420, Sep. 20, 1991.
Grusby et al., Annual Review of Immunology, vol. 13, pp. 417-435, 1995.
Denzin et al., Immunity, vol. 1, pp. 595-606,. Oct. 1, 1994.
H2-M Mutant Mice Are Defective in The Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection, W. David Martin, Cell, vol. 84, 543-550, Feb. 23, 1996.
Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway, Toru Miyazaki, Cell, vol. 84, 531-541, Feb. 23, 1996.
Role of The Thrombin Receptor in Development and Evidence for a Second Receptor, Andrew J. Connolly, Nature, vol. 381, 516-519, Jun. 6, 1996.
Amplified RNA Synthesized from Limited Quantities of Heterogeneous cDNA, Russell N. Van Gelder, Proc. Natl. Acad. USA, vol. 87, 1663-1667, Mar. 1990.
Antigen Presentation and T Cell Development in H2-M-Deficient Mice, Wai-Ping Fung-Leung, Science, vol. 271, 1278-1281, Mar. 1,1996.
Karlsson Lars
Leung Wai-Ping
Peterson Per A.
Zhou Lubing
Campell Bruce R.
Martin Jill D.
Ortho Pharmaceutical Corp.
Wallen III John W.
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