H.sub.3 receptor ligands of the phenyl-alkyl-imidazoles type

Details H.sub.3 receptor ligands of the phenyl-alkyl-imidazoles type H.sub.3 receptor ligands of the phenyl-alkyl-imidazoles type

1998-11-05

1999-11-23

Powers, Fiona T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483461, C07D23364, A61K 31415

Patent

active

059901470

ABSTRACT:
Disclosed are novel phenyl-alkyl-imidazoles of the formula ##STR1## or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification.
Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula I (or a salt or solvate thereof) to a patient in need of such treatment.
Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula I in combination or admixture with a histamine H.sub.1 receptor antagonist.

REFERENCES:
patent: 5559113 (1996-09-01), Schwartz et al.
patent: 5578616 (1996-11-01), Aslanian et al.
patent: 5708171 (1998-01-01), Schwartz et al.
patent: 5869479 (1997-08-01), Kreutner et al.
Partial translation for WO 9629315, Sep. 1996.

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