Gyrase inhibitors and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S333000, C514S256000, C544S335000, C546S274400, C546S256000

Reexamination Certificate

active

08034832

ABSTRACT:
The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

REFERENCES:
patent: 3856957 (1974-12-01), Seng et al.
patent: 4174400 (1979-11-01), Mrozik
patent: 4512998 (1985-04-01), Nafissi-Varchei
patent: 5529998 (1996-06-01), Habich et al.
patent: 5643935 (1997-07-01), Dykstra et al.
patent: 6632809 (2003-10-01), Grillot et al.
patent: RE40245 (2008-04-01), Grillot et al.
patent: 7414046 (2008-08-01), Grillot et al.
patent: 2004/0043989 (2004-03-01), Grillot et al.
patent: 2004/0235886 (2004-11-01), Charifson et al.
patent: 2005/0038247 (2005-02-01), Charifson et al.
patent: 2005/0256136 (2005-11-01), Charifson et al.
patent: 2006/0025424 (2006-02-01), Charifson et al.
patent: 2006/0122196 (2006-06-01), Charifson et al.
patent: 1055668 (2000-11-01), None
patent: 0738726 (2010-11-01), None
patent: 99/35155 (1999-07-01), None
patent: 00/49015 (2000-08-01), None
patent: 00/71522 (2000-11-01), None
patent: 03105846 (2003-12-01), None
patent: 2005012292 (2005-02-01), None
patent: 2007/056330 (2007-05-01), None
patent: 02/060879 (2008-08-01), None
Kus et al., “Synthesis and Antimicrobial Activities of 5-fluoro-1,2,6-trisubstituted Benzimidazole Carboxamide and Acetamide Derivatives” Arch. Pharm. Pharm. Med. Chem., vol. 334, No. 11, pp. 361-365, 2001.
Sun et al., “Synthesis and Evaluation of Terbenzimidazoles as Topoisomerase I Inhibitors” J. Med. Chem., vol. 38, No. 18, pp. 3638-3644, 1995.
Hubschwerlen et al., “Pyrimido[1,6-a]benzimidazoles: A New Class of DNA Gyrase Inhibitors” J. Med. Chem, vol. 35, No. 8, pp. 1385-1392, 1992.
Tanitame et al. “Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity” Bioorganic & Medicinal Chemistry Letters 2004, 14, 2857-2862.
Guven et al. “Synthesis and Antimicrobacterial Activity of Some Novel Furyl and Benzimidazole Substituted Benzyl Ethers” Journal of Heterocyclic Chemistry 2007, 44, 731.
He et al. “Synthesis and biological evaluations of novel benzimidazoles as potential antibacterial agents.” Bioorganic & Medicinal Chemistry Letters 2004, 14, 1217-1220.
MayoClinic “Antibiotic associated diarrhea” Mayoclinic.com. (2007).
Wassenaar “Bacteria; more than pathogens” Am. Ins. biol. Sci. internet p. 1-7 (2002).
Webster's Dictionary (1984) p. 933.
Singh, S.K., et al., “Studies in antiparasitic agents: Part 13—Synthtesis of 4-aryl-2-substitutedamino-thiazoles as potential anthelmintics,” Indian J. Chem., 28B(9):786-789 (1989).
Beers, M. H., and Berkow, R., “The Merck Manual of Diagnosis and Therapy”, 7th Edition, Chapter 156—Bacteremia and Septic Shock, Merck Research Laboratories, Whitehouse Station, NJ, pp. 1143-1147 (1999).
Nicolaus B. J. R., “Symbiotic Approach to Drug Design,” Decision Making in Drug Research, pp. 173-186 (1983).
Pea et al., PubMed Abstract (Clin Pharmacokinet. 44(10):1009-34)2005.
Snyder et al., PubMed Abstract (J. Med. Liban. 48(4):208-14) Jul.-Aug. 2000.
Eckert et al. “The antifungal activity of . . . ” CA 93:39290 (1980).

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