Gut commensal bacterium and methods of using the same

Details Gut commensal bacterium and methods of using the same Gut commensal bacterium and methods of using the same

2011-08-02

2011-08-02

Robinson, Hope (Department: 1652)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

C424S093200, C435S252100, C435S325000, C435S069100, C435S006120, C435S320100

Reexamination Certificate

active

07988961

ABSTRACT:
The invention provides gut commensal bacteria that have been modified to express one or more biologically active polypeptides or protiens, the bacteria includes a promoter, such as a xylanase promoter, which is induced in response to the presence of xylan in the diet and which regulates the expression of the biologically active polypeptide or protien.

REFERENCES:
patent: 0 965 641 (1999-12-01), None
Whitehead, et al.,Heterologous expression of the Bacteroides ruminicola xylananse gene in Bacteroides fragilis and Bacteroides uniformis, Jul. 21, 1989, pp. 61-65, vol. 66, Fems Microbiology Letters.
Steidler, et al.,Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukinJul. 10, 2003, pp. 785-789, vol. 21, Nature Biotechnology , Nature Publishing Group.
Steidler, et al.,Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10, Aug. 25, 2000, pp. 1352-1355, vol. 289, Science, American Association for the Advancement of Science, US.
Selinger, et al.,The Rumen: A Unique Source of Enzymes for Enhancing Livestock Production, Oct. 1996, pp. 263-284, vol. 2, No. 5, Anaerobe.
Farrar, et al.,Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan, May 5, 2005, pp. 1191-1997, vol. 98, Journal of Applied Microbiology.
International Search Report-International Application No. PCT/GB2006/000222.

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