Gustducin γ subunit materials and methods

Details Gustducin γ subunit materials and methods Gustducin γ subunit materials and methods

2002-06-03

2008-01-01

Saoud, Christine J. (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S350000, C536S023100, C435S320100, C435S235100, C435S069100

Reexamination Certificate

active

07314716

ABSTRACT:
Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (γ) subunit of gustducin, as well as polynucleotide sequences encoding the γ subunit. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin γ subunit, methods for identifying such taste modifying agents and various taste modifying agents.

REFERENCES:
patent: 3647482 (1972-03-01), Yueh
patent: 3784390 (1974-01-01), Hijiya et al.
patent: 4243691 (1981-01-01), Mohlenkamp, Jr. et al.
patent: 4544559 (1985-10-01), Gil et al.
patent: 4562020 (1985-12-01), Hijiya et al.
patent: 4623394 (1986-11-01), Nakamura et al.
patent: 4826824 (1989-05-01), Schiffman
patent: 4994442 (1991-02-01), Gil et al.
patent: 5232735 (1993-08-01), Kurtz et al.
patent: 5411945 (1995-05-01), Ozaki et al.
patent: 5518902 (1996-05-01), Ozaki et al.
patent: 5631038 (1997-05-01), Kurtz et al.
patent: 5631231 (1997-05-01), Kurtz et al.
patent: 5631232 (1997-05-01), Kurtz et al.
patent: 5631240 (1997-05-01), Kurtz et al.
patent: 5631252 (1997-05-01), Kurtz et al.
patent: 5631272 (1997-05-01), Kurtz et al.
patent: 5631292 (1997-05-01), Kurtz et al.
patent: 5631294 (1997-05-01), Kurtz et al.
patent: 5631295 (1997-05-01), Kurtz et al.
patent: 5631299 (1997-05-01), Kurtz et al.
patent: 5637618 (1997-06-01), Kurtz et al.
patent: 5639788 (1997-06-01), Kurtz et al.
patent: 5641795 (1997-06-01), Kurtz et al.
patent: 5641799 (1997-06-01), Kurtz et al.
patent: 5641811 (1997-06-01), Kurtz et al.
patent: 5641812 (1997-06-01), Kurtz et al.
patent: 5643894 (1997-07-01), Kurtz et al.
patent: 5643941 (1997-07-01), Kurtz et al.
patent: 5643945 (1997-07-01), Kurtz et al.
patent: 5643955 (1997-07-01), Kurtz et al.
patent: 5643956 (1997-07-01), Kurtz et al.
patent: 5646122 (1997-07-01), Kurtz et al.
patent: 5650403 (1997-07-01), Kurtz et al.
patent: 5654311 (1997-08-01), Kurtz et al.
patent: 5665755 (1997-09-01), Kurtz et al.
patent: 5688662 (1997-11-01), Margolskee
patent: 5693756 (1997-12-01), Li et al.
patent: 5700792 (1997-12-01), Kurtz et al.
patent: 5703053 (1997-12-01), Kurtz et al.
patent: 5817759 (1998-10-01), Margolskee
patent: 5853792 (1998-12-01), Zolotov et al.
patent: 5866608 (1999-02-01), Kurtz et al.
patent: 6008250 (1999-12-01), Kurtz et al.
patent: 6015792 (2000-01-01), Kurtz et al.
patent: 2001/0022964 (2001-09-01), Leung et al.
patent: 2003/0157568 (2003-08-01), Zuker et al.
patent: 497 136 (1970-11-01), None
patent: 0 059 363 (1984-12-01), None
patent: 0 122 400 (1987-07-01), None
patent: 0 125 021 (1993-09-01), None
patent: 0 416 667 (1993-09-01), None
patent: 45-51605 (1970-06-01), None
patent: 48-17044 (1973-03-01), None
patent: 48-10227 (1973-04-01), None
patent: 61-271969 (1986-12-01), None
patent: 1285157 (1989-11-01), None
patent: 52-36885 (1993-09-01), None
patent: 10108655 (1998-04-01), None
patent: 11-169131 (1999-06-01), None
patent: 2000-300206 (2000-10-01), None
patent: 2001-269149 (2001-10-01), None
patent: 2003265 (1993-11-01), None
patent: WO 91/09955 (1991-07-01), None
patent: WO 92/20808 (1992-11-01), None
patent: WO 94/12650 (1994-06-01), None
patent: WO 97/04666 (1997-02-01), None
patent: WO 98/20862 (1998-05-01), None
patent: WO 98/26763 (1998-06-01), None
patent: WO 98/26780 (1998-06-01), None
patent: WO 99/17753 (1999-04-01), None
patent: WO 00/038536 (2000-07-01), None
Ming et al, Proc Natl. Acad. Sci. USA, vol. 95, 8933-8938, Jul. 1998.
Ueda et al, J. Biol Chem., vol. 369, 4388-4395, Feb. 1994.
Ruiz-Avila et al , Proc Natl. Acad. Sci. USA, vol. 98, 8868-8873, Jul. 2001.
He et al Chem. Senses, vol. 27, 719-727, 2002.
Huang et al Nature Neuroscience, vol. 2, No. 12, 1055-1062, Dec. 1999.
Lindorfer et al ,J. Biol Chem., vol. 273, No. 51, 34429-34436, Dec. 1998.
Rahmatullah et al, J. Biol Chem., vol. 270, 2946-2951, Feb. 1995.
Blake et al, J. Biol Chem., vol. 276, 49267-49274, 2001.
Cane et al., “Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations,”Science282(5386):63-68 (1998).
Capecchi, “Altering the Genome by Homologous Recombination,”Science244(4910):1288-1292 (1989).
Cheung et al., “Specific Activation of Gsby Synthetic Peptides Corresponding to an Intracellular Loop of the β-Adrenergic Receptor,” FEBS Lett. 279(2):277-280 (1991).
Duby et al., “Using Synthetic Nucleotides as Probes,” in Current Protocols in Molecular Biology 6.4.1-6.4.10 (Ausubel et al. eds., Supp. 2 1988, Supp. 9 1990, Supp. 13 1995).
Houghten et al., “Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery,”Nature354(6348):84-86 (1991).
Jones & Reed, “Golf: An Olfactory Neuron Specific-G Protein involved in Odorant Signal Transduction,”Science244(4906):790-795 (1989).
Lam et al., “A New Type of Synthetic Peptide Library for Identifying Ligand-binding Activity,”Nature354(6348):82-84 (1991).
Lerea et al., “Identification of Specific Transducin α Subunits in Retinal Rod and Cone Photoreceptors,”Science234(4772):77-80 (1986).
Peri et al., “Rapid Entry of Bitter and Sweet Testants Into Liposomes and Taste Cells: Implications for Signal Transduction,”Am. J. Physiol. Cell Physiol.278:C17-C25 (2000).
Quertermous, “Plating Libraries and Transfer to Filter Membranes,” in Current Protocols in Molecular Biology 6.1.1-6.1.4 (Ausubel et al. eds., Supp. 13 1995 & Supp. 34 1996).
Rahmatullah & Robishaw, “Direct Interaction of the α and γ Subunits of the G Proteins,”J. Biol. Chem.269(5):3574-3580 (1994).
Ruiz-Avila et al., “An In Vitro Assay Useful to Determine the Potency of Several Bitter Compounds,”Chem. Senses25:361-368 (2000).
Ruiz-Avila et al., “Coupling of Bitter Receptor to Phosphodiesterase Through Transducin in Taste Receptor Cells,”Nature376:80-85 (1995).
Sambrook et al., Molecular Cloning 9.47-9.51 (2d ed. 1989).
Schmidt et al., “Specificity of G Protein β and γ Subunit Interactions,”J. Biol. Chem.267(20)13807-13810 (1992).
Scott & Smith, “Searching for Peptide Ligands with an Epitope Library,”Science249(4967):386-390 (1990).
Strauss, “Hybridization with Radioactive Probes,” in Current Protocols in Molecular Biology 6.3.1-6.3.6 (Ausubel et al. eds., 1987, Supp. 2 1988, Supp.13 1995, Supp. 24 1993).
Tareilus et al., “Approaches for Monitoring Rapid Kinetics of Second Messenger Signaling,” in Current Techniques & Protocols 193-202 (1995).
Weis, “Planting and Transferring Cosmid and Plasmid Libraries,” in Current Protocols in Molecular Biology 6.2.1-6.2.3 (Ausubel et al eds., 1987 & Supp. 24 1993).
Wong et al., “Biochemical and Transgenic Analysis of Gustducin's Role in Bitter and Sweet Transduction,” in LXI Cold Spring Harbor Symposia on Quantitative Biology 173-184 (1996).
Akabas et al., “A Bitter Substance Induces a Rise in Intracellular Calcium in a Subpopulation of Rat Taste Cells,”Science242:1047-50 (1988).
Amer & Kreighbaum, “Cyclic Nucleotide Phosphodiesterases: Properties, Activators, Inhibitors, Structure-activity Relationships, and Possible Role in Drug Development,”J. Pharm. Sci.64(1):1-37 (1975).
Asano et al., “Reconstitution of Catecholamine-stimulated Binding of Guanosine 5′-O- (3-Thiotriphosphate) to the Stimulatory GTP-binding Protein of Adenylate Cyclase,”Biochem.23:5460-7 (1984).
Avenet & Lindemann, “Perspectives of Taste Reception,”J. Membr. Biol.112(1)1-8 (1989).
Avenet et al., “Transduction in Taste Receptor Cells Requires cAMP-dependent Protein Kinase,”Nature331:351-4 (1988).
Axelsson et al., “The Influence of Dietary Nucleotides on Erythrocyte Membrane Fatty Acids and Plasma Lipids in Preterm Infants,”Acta Paediatr.86(5):539-44 (1997).
Bartoshuk, “Taste Mixtures: Is Mixture Suppression Related To C

Affiliated with

Also associated with

Rating

Gustducin γ subunit materials and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gustducin γ subunit materials and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gustducin γ subunit materials and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3964878