Guanylhydrazones and medicaments containing them

Details Guanylhydrazones and medicaments containing them Guanylhydrazones and medicaments containing them

1977-10-13

1980-10-07

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424326, 260564F, 260456A, C07C14302, C07C13310, A61K 31255, A61K 31155

Patent

active

042268850

ABSTRACT:
New guanylhydrazones of phenoxyacetic acid. These guanylhydrazones, also their physiologically acceptable salts, are characterized by the following general formula I in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R and R' have the meanings which are hereinafter described. ##STR1## The new guanylhydrazones are useful as medicaments, in particular antimitotic, IMAO and platelet antiagregant activity.

REFERENCES:
patent: 3130232 (1964-04-01), Paquette
patent: 3131218 (1964-04-01), Spickett et al.
patent: 3816531 (1974-06-01), Bruce et al.
Chemical Abstr., vol. 49, col. 168(e) (1955).
Chemical Abstr., vol. 55, col. 2540(g) (1961).
Mutschler et al., Biochemical Pharmacology, vol. 19, pp. 9-15, (Pergamon Press. 1970).
Morrison & Boyd, "Organic Chemistry", 3rd Ed., pp. 641-643 (1973).

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