Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-17
2005-05-17
Andres, Janet (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S320100, C435S325000, C530S350000
Reexamination Certificate
active
06894157
ABSTRACT:
The present invention relates to an expression vector comprising the Guanylate Binding Protein 1 (GBP-1) gene or parts thereof. The introduction of said vector comprising said gene or parts thereof in sense or antisense orientation into cells can be used to induce phenotypical changes of said cells and can, thus, be used for modulation of cell differentiation. Additionally, the present invention provides, inter alia, a method for determination of the stage of cellular differention by using GBP-1 gene expression as a marker.
REFERENCES:
patent: 5256553 (1993-10-01), Overell
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5652122 (1997-07-01), Frankel et al.
patent: 5670617 (1997-09-01), Frankel et al.
patent: 5674980 (1997-10-01), Frankel et al.
patent: 5747641 (1998-05-01), Frankel et al.
patent: 5804604 (1998-09-01), Frankel et al.
patent: 5871965 (1999-02-01), Bandman et al.
patent: 6265189 (2001-07-01), Paoletti et al.
patent: WO 9818911 (1998-05-01), None
patent: WO 0012737 (2000-03-01), None
GenBank accesion No. AA296543, Kerlavage et al., 1997.*
Anderson, Sylvia L. et al., 1999, “Interferon-Induced Guanylate Binding Protein-1 (GBP-1) Mediates an Antiviral Effect against Vesicular Stomatitis Virus and Encephalomyocarditis Virus”,Virology, vol. 256, pp. 8-14.
Cheng, Yih-Shyum E. et al., 1983, “Interferon Induction of Fibroblast Proteins with Guanylate Binding Activity”,The Journal of Biological Chemistry, vol. 258, pp. 7746-7750.
Cheng, Yih-Shyum E. et al., 1991, “Interferon-Induced Guanylate-Binding Proteins Lack an N (T) KXD Consensus Motif and Bind GMP in Addition to GDP and GTP”,Molecular and Cellular Biology, vol. 11, No. 9, pp. 4717-4725.
Cheng, Yih-Shyun E. et al., 1988, “Accumulation of Guanylate Binding Proteins in Patients Treated with Interferons”,Journal of Interferon Research, vol. 8, pp. 385-391.
Decker, Thomas et al., 1991, “Two Distinct Alpha-Interferon-Dependent Signal Transduction Pathways May Contribute to Activation of Transcription of the Guanylate-Binding Protein Gene”,Molecular and Cellular Biology, vol. 11, No. 10, pp. 5147-5153.
Lew, Daniel J. et al., 1991, “Overlapping Elements in the Guanylate- Binding Protein Gene Promoter Mediate Transcriptional Induction by Alpha and Gamma Interferons”,Molecular and Cellular Biology, vol. 11, No. 01, pp. 182-191.
Schwemmle, Martin et al., 1994, “The Interferon-induced 67-kDa Guanylate-binding Protein (hGBP1) Is a GTPase That Converts GTP to GMP”,The Journal of Biological Chemistry, vol. 269, No. 15, pp. 11299-11305.
Cornali Emmanuelle
Stürzl Michael
Andres Janet
Hamilton Brook Smith & Reynolds P.C.
Sturzl Michael
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