Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2010-03-03
2011-12-13
Chandra, Gyan (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S007100
Reexamination Certificate
active
08076455
ABSTRACT:
The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”, cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.
REFERENCES:
patent: 5858716 (1999-01-01), Elshourbagy et al.
patent: 6475753 (2002-11-01), Ruben et al.
patent: 6783969 (2004-08-01), Tang et al.
patent: 2002/0119493 (2002-08-01), Glucksmann
patent: 1273659 (2003-01-01), None
patent: 99/66041 (1999-12-01), None
patent: 00/39164 (2000-07-01), None
patent: 00/58462 (2000-10-01), None
patent: 01/46414 (2001-06-01), None
patent: 01/77325 (2001-10-01), None
patent: 02/08258 (2002-01-01), None
patent: 02/10387 (2002-02-01), None
patent: 02/16548 (2002-02-01), None
patent: 02/072823 (2002-09-01), None
patent: 02/084286 (2002-10-01), None
patent: 02/088355 (2002-11-01), None
Ganz et al., Biochem. Biophys. Res. Comm. 178: 1386-1392, 1991.
Weigel, “Steroid hormone receptors and their regulation by phosphorylation”, Biochem. J. (1996), vol. 319, pp. 657-668.
Supplementary partial European search report from corresponding European patent appln. Serial No. 01 97 6875.
Wigley, “Site-specific transgene insertion: . . . ”, Reprod. Fertil. Dev. (1994), vol. 6, pp. 585-588.
Bonaldo, “Normalization and subtraction: two approaches . . . ”, Genome Research (1996), vol. 6, pp. 791-806.
Bowie, “Deciphering the message in protein sequences: . . . ”, Science (1990), vol. 247, pp. 1306-1310.
Campbell, “Totipotency or multipotentiality of cultured cells: . . . ”, Theriogenology (1997), vol. 47, pp. 63-72.
Houten, “Endocrine functions of bile acids”, The EMBO Journal (2006), vol. 25, pp. 1419-1425.
Katsuma, “Bile acids promote glucagon-like peptide-1 secretion . . . ”, Biochem. & Biophys. Res. Comm., (2005), vol. 329, pp. 386-390.
Kawamata, “A G protein-coupled receptor . . . ”, J. Biol. Chem. (2003), vol. 278, pp. 9435-9440.
Maruyama, “Identification of membrane-type receptor . . . ”, Biochem. & Biophys. Res, Comm. (2002), vol. 298, pp. 714-719.
Phillips, “The challenge of gene therapy . . . ”, J. Pharmacy & Pharmacology (2001), vol. 53, pp. 1169-1174.
The Sanger Centre, “Toward a complete human genome sequence”, Genome Research (1998), vol. 8, pp. 1097-1108.
Wang, “Rapid analysis of gene expression (RAGE) . . . ”, Nucleic Acids Research (1999), vol. 27, pp. 4609-4618.
Watanabe, “Bile acids induce energy expenditure by promoting intracellular . . . ”, Nature (2006), vol. 439, pp. 484-489.
Wells, “Additivity of mutational effects in proteins”, Biochemistry (1990), vol. 29, pp. 8509-8517.
Itadani Hiraku
Maruyama Takaharu
Nakamura Takao
Tanaka Ken'ichi
Chandra Gyan
Merck Sharp & Dohme Corp.
Reilly John David
Thampoe Immac J.
LandOfFree
Guanosine triphosphate (GTP)-binding protein-coupled... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Guanosine triphosphate (GTP)-binding protein-coupled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanosine triphosphate (GTP)-binding protein-coupled... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4255826