Guanosine monophosphate reductase

Details Guanosine monophosphate reductase Guanosine monophosphate reductase

2006-03-28

2006-03-28

Nashed, Nashaat T. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S191000, C424S094400, C536S023200, C536S023500

Reexamination Certificate

active

07018822

ABSTRACT:
The present invention provides a human guanosine monophosphate reductase (HGMPR) and polynucleotides which identify and encode HGMPR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HGMPR and a method for producing HGMPR. The invention also provides for agonists, antibodies, or antagonists specifically binding HGMPR, and their use, in the prevention and treatment of diseases associated with expression of HGMPR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HGMPR for the treatment of diseases associated with the expression of HGMPR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HGMPR.

REFERENCES:
Kanno, H et al., “Two Structural Genes on Different Chromosomes Are Required for Encoding the Major Subunit of Human Red Cell Glucose-6-Phosphate Dehydrogenase”Cell58:595-606 (1989).
Streeter, DG and Robins, RK, “Comparative In Vitro Studies of Tiazofurin and a Selenazole Analog”Biochem. Biophys. Res. Comm.115(2):544-550 (1983).
Page, T et al., “Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells”Cancer. Chemother Pharmacol15:59-62 (1985).
Prajda, N et al., “Sequential Impact of Tiazofurin and Ribavirin on the Enzymic Program of the Bone Marrow”Cancer Research53:5982-5986 (1993).
Franklin, TJ et al., “The Inhibition of Nucleic Acid Synthesis by Mycophenolic Acid”Biochem. J.113:515-524 (1969).
Andrews, SC and Guest, Jr, “Nucleotide sequence of the gene encoding the GMP reductase ofEscherichia coliK12”Biochem J255:35-43 (1988) (GI 473772).
Kondoh, T et al., “Genomic structure and expression of human guanosine monophosphate reductase”Hum Genet88:219-224 (1991) (GI 544455).
Hillier, L. et al., (Accession No. N44897) EMBL Database, Geneva, Switzerland.
Hillier, L. et al., (Accession No. N28887) EMBL Database, Geneva, Switzerland.
Hillier, L. et al., (Accession No. AA004431) EMBL Database, Geneva, Switzerland.
Hillier, L. et al., (Accession No. W60937) EMBL Database, Geneva, Switzerland.

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