Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1983-10-06
1985-11-05
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
435119, 435826, C07D47318, A61K 3152, C12P 1718, C12R 104
Patent
active
045515298
ABSTRACT:
A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the antimicrobial/antitumor compound 2-amino-1,9-dihydro-6H-purine-6-one-7-oxide, commonly known as guanine-N.sup.7 -oxide.
Guanine-N.sup.7 -oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound.
The antibiotic/antitumor compound guanine-N.sup.7 -oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed as is a method of treating microbial infections in a mammal or of treating tumors in a mammal.
REFERENCES:
patent: 3920664 (1975-11-01), Clemens et al.
patent: 4166182 (1979-08-01), Kornfeld et al.
Brown G. et al. Cancer Research 25:986-991 (1965).
Delia & Brown, G., J. Org. Chem. 31:178-181, (1966).
Sugiura & Brown, G., Cancer Research 27:925-931 (1967).
Wolke & Brown, G., J. Org. Chem. 34:978-981 (1969).
Wolke et al., J. Org. Chem., 34:981-983, (1969).
Watson et al., J. Org. Chem. 38:3046-3048, (1973).
Watson, J. Org. Chem. 39:2911-2916, (1974).
Brown, R. et al., J. Chem. Soc., Perkin Trans. 1 9:pp. 1003-1009, (1977).
Chemical Abstracts 87:84942r, 89:210598n, 70:115132g.
Organic Syntheses, collective vol. 3, pp. 262-267, John Wiley & Sons, New York, 1955.
Livingston et al., J. Am. Chem. Soc. , vol 47, pp. 2069-2082, (1925).
French James C.
Hokanson Gerard C.
Kern Donald L.
Daus Donald G.
Janssen Jerry F.
Kapner Stephen M.
Warner-Lambert & Company
LandOfFree
Guanine-N.sup.7 -oxide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Guanine-N.sup.7 -oxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Guanine-N.sup.7 -oxide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-296427