Guanine derivatives

Details Guanine derivatives Guanine derivatives

1981-09-16

1992-10-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, C07D47318, A61K 3152

Patent

active

051571200

ABSTRACT:
Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels.

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Millership et al., International Jour. of Pharmaceutics, vol. 28, (1986), pp. 1-9.
Greene, Protective Groups in Organic Synthesis, pp. 44-46 (1980).
Gillen, M. F., "Synthesis and Properties of Novel Nucleoside and Nucleotide Ana Logues", pp. 1-83, Apr. 1980.
Bryant et al., J. Org. Chem., 44 (21) 3733 (1979).
Gillen, Dissertation Abst. International, vol. 41, No. 8, Feb. 1981.
Ogilvie et al., "Ring Open Analogues of Deoxynucleotides", Tetrahedron Letters, vol. 21, pp. 327-330 (1980).

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