Guanine analog phosphates

Details Guanine analog phosphates Guanine analog phosphates

1996-04-22

1998-08-04

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544243, 544276, 544277, C07D47318, C07F 96561

Patent

active

057895899

ABSTRACT:
Disclosed are novel prodrugs represented by the following structural formulas: ##STR1## Z is oxygen or sulfur; n is 1 or 2; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a group which can be metabolized in vivo to a give a modified A such that the phosphoester bond (modified A)--O undergoes cleavage in vivo. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

REFERENCES:
patent: 4146715 (1979-03-01), Schaffer
patent: 4294831 (1981-10-01), Schaeffer
patent: 4806642 (1989-02-01), Sircar et al.
patent: 4816447 (1989-03-01), Ashton et al.
patent: 4845084 (1989-07-01), Hannah et al.
patent: 5055458 (1991-10-01), Bailey et al.

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