Guanidio derivatives of kasugamycin and their production

Details Guanidio derivatives of kasugamycin and their production Guanidio derivatives of kasugamycin and their production

1972-01-24

1976-07-06

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260210R, 424180, C07H 1522

Patent

active

039681009

ABSTRACT:
New guanidino derivatives of kasugamycin in which the oxalamidino group at the 4-position of kasugamycin molecule has been replaced by different guanidino groups are produced and found to show an improved antibacterial activity against Gram negative bacteria and a decreased toxicity to man and animals, as compared to kasugamycin itself. The new guanidino derivatives of kasugamycin may readily be produced by reacting an amine with an isourea derivative of kasugamycin which has been prepared by reacting sodium hypobromite with kasugamycin and then treating the resulting cyanamide derivative with hydrogen chloride in methanol.

REFERENCES:
patent: 3456009 (1969-07-01), Green et al.
patent: 3647779 (1972-03-01), Schmitz
patent: 3652535 (1972-03-01), Keil et al.
Suhara et al., "Chem. Abst." vol. 64, 1966, p. 15965(d).

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