Guanidinopyrimidine compounds, compositions and method of using

Details Guanidinopyrimidine compounds, compositions and method of using Guanidinopyrimidine compounds, compositions and method of using

1981-03-24

1982-06-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544323, A61K 31505, C07D23930, C07D23948, C07D23950

Patent

active

043362540

ABSTRACT:
2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia.

REFERENCES:
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patent: 2422887 (1947-06-01), Curd et al.
patent: 2487569 (1949-11-01), Mackey
patent: 3284188 (1966-11-01), Amagasa et al.
Boggiano, et al. "J. Pharm. & Pharmacol.", vol. 13, 1961, pp. 567-574.
King et al., "J. Chem. Soc.", 1947, pp. 726-734.
Carbon, "J. Org. Chem.", vol. 26, 1961, pp. 455-461.
Buehler et al., "Chem. Ber.", vol. 99, 1966, pp. 2997-3007.

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