Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-01-22
1987-07-28
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 514218, 514228, 514230, 514233, 514241, 514242, 514245, 514252, 514269, 514272, 514274, 514316, 514318, 514326, 514340, 514341, 514359, 514361, 514362, 514363, 514364, 514365, 514369, 514370, 514372, 514374, 514376, 514377, 514378, 514380, 514383, 514384, 514385, 514397, 514398, 514402, 514403, 514406, 514407, 540544, 540553, 540575, 540596, 540597, 540598, 540601, 540602, 540603, 544 2, 544 3, 544 7, 544 8, 544 55, 544 56, 544 586, 544 63, 544 66, 544 67, 544 72, 544 82, 544 96, 544 98, 544111,
Patent
active
046832289
ABSTRACT:
A guanidine derivative of the formula I: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydroxy radical and into which is optionally inserted, as part of the backbone of the chain, one or two groups selected from oxygen and sulphur atoms and NH and 1-6C N-alkyl radicals; and the pharmaceutically-acceptable acid additions salts thereof. Pharmaceutical compositions and methods of manufacture are also described. The compound of the formula I is a histamine H-2 antagonist and is therefore useful in ulcer therapy.
REFERENCES:
patent: 4447441 (1984-05-01), Yellin et al.
Burger's Medicinal Chem., Edit. by Wolff, 4th Edit., 1981, pp. 537-540 and 507-509.
Medicinal Chem., Edit by Burger, 2nd Edit., 1960, pp. 72-88.
Kirkland Karin M.
Mant Derrick M.
Briscoe Kurt G.
ICI Americas Inc.
Imperial Chemical Industries plc
Jiles Henry R.
Miano Rosemary M.
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