Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-09-26
1979-01-30
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546209, 546210, 546211, A61K 3144, C07D21378
Patent
active
041373197
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
REFERENCES:
patent: 4034101 (1977-07-01), Durant et al.
patent: 4062967 (1977-12-01), Durant et al.
Durant Graham J.
Ganellin Charon R.
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Rotman Alan L.
Smith Kline & French Laboratories Limited
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