Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1976-04-20
1978-01-24
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602948D, 2602948G, 2602948H, 260296R, A61K 31395, C07D21383
Patent
active
040704726
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
REFERENCES:
patent: 3917626 (1975-11-01), Edwards
Conant et al., "The Chemistry of Organic Compounds" (MacMillan N.Y. 1939) p. 264.
Durant Graham John
Ganellin Charon Robin
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Rotman Alan L.
Smith Kline & French Laboratories Limited
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