Guanidino, thioureido and isothioureido derivatives containing i

Details Guanidino, thioureido and isothioureido derivatives containing i Guanidino, thioureido and isothioureido derivatives containing i

1977-10-19

1978-09-12

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548377, 2602948E, 548378, 2602948G, 2602948R, 2602948H, 260295AM, 260296D, 260296R, 2603068A, 2603068R, 260307H, 260307R, 260308R, 424250, 424251, 424263, 424267, 424270, 424272, 548301, 548315, 548316, 548318, 548319, 548321, 548337, 548342, 548358, 548362, 548364, 548365, 548367, 548374, C07D23364, A61K 31415

Patent

active

RE0297615

ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N', N"-disubstituted guanidino), N-(N'-substituted thiouredo), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.

REFERENCES:
Conant et al. The Chemistry of Organic Compounds p. 264, N.Y. MacMillan, 1939.

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